| 1 |
35429966 | Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways. | 2022 Apr 16 |
6 |
| 2 |
34094678 | Minnelide, a prodrug, inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb. | 2021 |
1 |
| 3 |
34348580 | Identification of potential targets of triptolide in regulating the tumor microenvironment of stomach adenocarcinoma patients using bioinformatics. | 2021 Dec |
1 |
| 4 |
34926700 | Potential Mechanisms of Triptolide against Diabetic Cardiomyopathy Based on Network Pharmacology Analysis and Molecular Docking. | 2021 |
1 |
| 5 |
29523159 | C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells. | 2018 Mar 9 |
1 |
| 6 |
30093863 | Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line. | 2018 |
1 |
| 7 |
30128010 | Triptolide induces protective autophagy and apoptosis in human cervical cancer cells by downregulating Akt/mTOR activation. | 2018 Sep |
2 |
| 8 |
28098861 | Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53. | 2017 Mar |
6 |
| 9 |
27004407 | Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer. | 2016 Apr 26 |
2 |
| 10 |
27461934 | Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway. | 2016 Sep |
1 |
| 11 |
27501149 | Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer. | 2016 |
1 |
| 12 |
25875797 | Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide. | 2015 May |
1 |
| 13 |
24213358 | Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway. | 2014 Jan |
1 |
| 14 |
24880464 | Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. | 2014 Jul |
3 |
| 15 |
25311433 | Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma. | 2014 Dec |
1 |
| 16 |
23233170 | Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes. | 2013 Feb |
1 |
| 17 |
24241349 | Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance. | 2013 Dec |
1 |
| 18 |
24244715 | Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. | 2013 |
8 |
| 19 |
22707197 | Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation. | 2012 Sep |
2 |
| 20 |
20607649 | MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status. | 2011 Jan |
2 |
| 21 |
21486687 | Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells? | 2011 Jul |
1 |
| 22 |
19524422 | Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. | 2009 Nov |
5 |
| 23 |
19885592 | Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism. | 2009 Dec |
3 |
| 24 |
18187663 | Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. | 2008 Apr 1 |
1 |
| 25 |
18379047 | Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells. | 2008 Apr |
1 |
| 26 |
18391982 | Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53. | 2008 Jul 31 |
5 |
| 27 |
17697526 | Inhibitory effect of triptolide on glioblastoma multiforme in vitro. | 2007 Jul-Aug |
2 |
| 28 |
17900403 | The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells. | 2007 Sep-Oct |
2 |
| 29 |
16316721 | Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells. | 2006 Sep 8 |
5 |
| 30 |
14555704 | PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. | 2003 Sep |
2 |
| 31 |
12171899 | Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. | 2002 Aug |
4 |
| 32 |
11753684 | Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. | 2001 Nov 29 |
8 |