Pub. Date : 2008 Jul 31
PMID : 18391982
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53. | triptolide | tumor protein p53 | Homo sapiens |
2 | Our results showed that a combined CDDP/triptolide therapy induced apoptosis in urothelial cancer cell lines with wild-type p53, but not in those with mutant-type p53 or normal human urothelium. | triptolide | tumor protein p53 | Homo sapiens |
3 | As the mechanism, triptolide suppressed CDDP-induced p53 transcriptional activity, leading to p21 attenuation, which promoted apoptosis via the activation of c-Jun N-terminal kinase (JNK) and Bax. | triptolide | tumor protein p53 | Homo sapiens |
4 | We further demonstrated that the functional regulation of p53 by triptolide was mediated by an intranuclear association of p53 with glycogen synthase kinase-3beta (GSK3beta), which was inactivated by protein kinase C (PKC). | triptolide | tumor protein p53 | Homo sapiens |
5 | We further demonstrated that the functional regulation of p53 by triptolide was mediated by an intranuclear association of p53 with glycogen synthase kinase-3beta (GSK3beta), which was inactivated by protein kinase C (PKC). | triptolide | tumor protein p53 | Homo sapiens |