pifithrin

tumor protein p53 ; Homo sapiens







240 Article(s)
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201 16778187 p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction. 2006 Jun 15 1
202 16844116 Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation. 2006 Aug 7 1
203 16971506 Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels. 2006 Dec 1
204 16982703 Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes. 2006 Dec 1
205 17065086 Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes. 2006 1
206 17341629 The histone deacetylase inhibitor FK228 distinctly sensitizes the human leukemia cells to retinoic acid-induced differentiation. 2006 Dec 3
207 15547111 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. 2005 Feb 1
208 15548639 Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. 2005 Feb 1
209 15800902 Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. 2005 Aug 20 4
210 15843497 The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. 2005 Aug 1
211 15865929 Prospective therapeutic applications of p53 inhibitors. 2005 Jun 10 1
212 15976193 Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. 2005 Sep 3
213 15983031 p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. 2005 Sep 2 3
214 16005638 Regulation of neuronal P53 activity by CXCR 4. 2005 Sep 1
215 16170037 Low-dose cisplatin protects human neuroblastoma SH-SY5Y cells from paclitaxel-induced apoptosis. 2005 Sep 1
216 16204041 Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53. 2005 Oct 1 1
217 16204064 Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival. 2005 Oct 1 2
218 14993250 NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. 2004 Mar 1 1
219 15001399 Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. 2004 Mar 15 1
220 15054096 Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways. 2004 Jun 11 2
221 15144874 The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. 2004 Jun 4
222 15145929 Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. 2004 Jul 16 2
223 15252149 Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. 2004 Jul 2
224 15302096 Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines. 2004 Sep 10 1
225 15331571 Regulation of steroidogenesis by p53 in macaque granulosa cells and H295R human adrenocortical cells. 2004 Dec 1
226 15378026 Wild-type p53 activates SAP expression in lymphoid cells. 2004 Nov 11 2
227 15498930 Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. 2004 Oct 1
228 12509264 Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. 2003 Jan 2 2
229 12556443 The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. 2003 Apr 4 1
230 12660163 p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. 2003 Apr 1 1
231 12884365 Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. 2003 Jul 8
232 12893085 Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells. 2003 Aug 12 1
233 12967348 The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro. 2003 Sep 11 3
234 11827710 Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. 2002 Feb 20 1
235 11889192 Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. 2002 Mar 1
236 11904448 Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. 2002 Mar 19 1
237 11931974 Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells. 2002 Apr 10 2
238 12131363 Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. 2002 Aug 3
239 12151395 Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. 2002 Oct 4 2
240 11279278 A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. 2001 Apr 1