alvocidib

tumor protein p53 ; Homo sapiens







20 Article(s)
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Pub. Year
#Total Relationships
1 29805751 The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells. 2018 May 4 1
2 27461656 Flavopiridol's antiproliferative effects in glioblastoma multiforme. 2016 Apr-Jun 1
3 25216351 Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol. 2014 Nov 1
4 22948151 Identification of HEXIM1 as a positive regulator of p53. 2012 Oct 19 1
5 20008633 Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders. 2010 Jan 20 1
6 21092078 Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. 2010 Nov 19 6
7 21159612 Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53. 2010 Dec 4
8 18381438 The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. 2008 Apr 1 6
9 18640498 Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. 2008 Aug 1 4
10 16503551 Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points. 2006 Mar 1
11 15897584 A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. 2005 May 15 1
12 16115936 Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points. 2005 Aug 15 1
13 15150125 Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. 2004 May 15 1
14 15297405 Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer. 2004 Aug 1 1
15 12688354 Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism. 2003 Feb 1
16 12432259 Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel. 2002 Jul-Aug 3
17 11482875 Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes. 2001 May-Jun 1
18 10811119 Flavopiridol binds to duplex DNA. 2000 May 1 1
19 10537362 Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. 1999 Oct 4
20 9808574 Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 1998 Nov 15 2