Platinum

tumor protein p53 ; Homo sapiens







116 Article(s)
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51 26086967 APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. 2015 Jun 18 4
52 26269716 Informative gene network for chemotherapy-induced peripheral neuropathy. 2015 2
53 26334096 A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer. 2015 Oct 13 1
54 24463159 TP53 K351N mutation-associated platinum resistance after neoadjuvant chemotherapy in patients with advanced ovarian cancer. 2014 Mar 2
55 25142144 A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma. 2014 Sep 15 1
56 25250341 Multiple analytical approaches demonstrate a complex relationship of genetic and nongenetic factors with cisplatin- and carboplatin-induced nephrotoxicity in lung cancer patients. 2014 1
57 25482940 Polymorphisms of p53 and MDM2 genes are associated with severe toxicities in patients with non-small cell lung cancer. 2014 1
58 22331493 Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. 2012 May 4
59 22333583 Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin. 2012 Mar 1 1
60 22590594 NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin. 2012 1
61 23285001 Synergistic role between p53 and JWA: prognostic and predictive biomarkers in gastric cancer. 2012 2
62 23936624 A texaphyrin-oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells. 2012 1
63 21792013 Expression of ERCC1, p53, and class III β-tubulin do not reveal chemoresistance in endometrial cancer: results from an immunohistochemical study. 2011 Aug 1
64 21863213 The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. 2011 1
65 21927014 Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells. 2011 Nov 1
66 22075440 Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients. 2011 Nov 10 1
67 22331725 TP53 gene status and human papilloma virus infection in response to platinum plus taxane-based chemotherapy of epithelial ovarian carcinomas. 2011 Oct-Dec 1
68 19499188 The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12. 2010 Aug 1
69 19609560 The role of p53 as a surrogate marker for chemotherapeutical responsiveness in ovarian cancer. 2010 Jan 1
70 19854294 Integrated genomics of chemotherapy resistant ovarian cancer: a role for extracellular matrix, TGFbeta and regulating microRNAs. 2010 Jan 1
71 20025464 DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles. 2010 Jan 1
72 20047843 Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. 2010 Sep 1
73 20101229 Alternative splicing of p53 and p73: the novel p53 splice variant p53delta is an independent prognostic marker in ovarian cancer. 2010 Apr 1 1
74 20562210 Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine. 2010 Aug 1 1
75 20940192 Association of DNA repair gene polymorphisms with response to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer. 2010 Nov 20 1
76 18575867 ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair. 2009 Mar 1
77 18937971 TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens. 2009 Jan 1
78 19150122 Prognostic value and clinicopathological significance of p53 and PTEN in epithelial ovarian cancers. 2009 Mar 1
79 20719132 [Prognostic Analysis of ERCC1, RRM1 and p53 Expressions in Postoperative Stage I-II Lung Cancer.]. 2009 May 20 1
80 18172257 Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival. 2008 Jan 1 1
81 18193228 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. 2008 Oct 3
82 18230133 TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: a non-randomized retrospective study. 2008 Jan 29 10
83 18281754 [Predictive markers for platinum-based chemotherapy]. 2008 Feb 1
84 18507046 Loss of heterozygosity, microsatellite instability and TP53 gene status in ovarian carcinomas. 2008 Mar-Apr 1
85 17640298 Excision repair cross-complementation group 1 predicts progression-free and overall survival in non-small cell lung cancer patients treated with platinum-based chemotherapy. 2007 Sep 1
86 17686239 [The predictive factors for the response to platinum/paclitaxel based first-line adjuvant chemotherapy in advanced ovarian cancer]. 2007 May 8 1
87 16739339 P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome. 2006 Jan-Feb 1
88 16750013 [Association of the responsiveness of advanced non-small cell lung cancer to platinum-based chemotherapy with p53 and p73 polymorphisms]. 2006 Feb 3
89 16127286 p53 Gene status and response to topotecan-containing chemotherapy in advanced ovarian carcinoma. 2005 2
90 16322298 Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo. 2005 Dec 1 4
91 14729645 Molecular determinants of the cytotoxicity of platinum compounds: the contribution of in silico research. 2004 Jan 1 1
92 15486204 Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin. 2004 2
93 12570658 Mechanisms controlling sensitivity to platinum complexes: role of p53 and DNA mismatch repair. 2003 Feb 2
94 12684687 The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. 2003 May 1
95 14513366 Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents. 2003 Dec 2
96 12006509 p53 mutations in leukemia and myelodysplastic syndrome after ovarian cancer. 2002 May 1
97 12093475 JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin. 2002 Jun 1 1
98 12440809 Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: biological data and clinical implications. 2002 4
99 12468337 Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role: a Southwest Oncology Group ancillary study. 2002 Oct 1
100 12478472 Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. 2002 Dec 3