Lapatinib

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







11 Article(s)
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1 34239043 A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers. 2021 Aug 1
2 30021909 Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis. 2018 Nov 1 1
3 30305055 Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL. 2018 Oct 11 1
4 28415602 ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib treatment likely by attenuating MCL1 and ERBB2 expression. 2017 May 30 2
5 25789974 Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. 2015 Mar 19 2
6 22219388 Obatoclax and lapatinib interact to induce toxic autophagy through NOXA. 2012 Apr 1
7 22357666 Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1. 2012 May 1
8 20571878 Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells. 2011 Dec 1
9 20855960 Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo. 2010 Nov 1 5
10 19823038 Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. 2009 Nov 4
11 18544666 Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation. 2008 Sep 2