Pub. Date : 2009 Nov
PMID : 19823038
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. | Lapatinib | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. | Lapatinib | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1 expression. | Lapatinib | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Collectively, our data demonstrate that Obatoclax mediated inhibition of MCL-1 rapidly enhances Lapatinib toxicity in tumor cells via a toxic form of autophagy and via AIF release from the mitochondrion. | Lapatinib | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |