Valsartan

angiotensin II receptor type 1 ; Homo sapiens







74 Article(s)
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1 35345577 Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan. 2022 6
2 33955183 The angiotensin II type 1 receptor blocker valsartan in the battle against COVID-19. 2021 Sep 3
3 32087363 Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. 2020 Mar - Apr 1
4 33203141 The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19. 2020 Nov 15 1
5 30998981 Downregulation of AT2R decreases the responsiveness of BKCa channels to angiotensin II in patients with hypertension. 2019 Jun 1
6 31307032 Angiotensin II Receptor Type 1 Antagonists Modulate Vascular Smooth Muscle Cell Proliferation and Migration via AMPK/mTOR. 2019 1
7 31803758 Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts. 2019 1
8 29500454 The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients. 2018 Mar 2 1
9 30212210 Trans and Cis Conformations of the Antihypertensive Drug Valsartan Respectively Lock the Inactive and Active-like States of Angiotensin II Type 1 Receptor: A Molecular Dynamics Study. 2018 Oct 22 1
10 27542885 Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension. 2017 Feb 2
11 28178430 Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway. 2017 May 20 2
12 28338173 Valsartan reduces AT1-AA-induced apoptosis through suppression oxidative stress mediated ER stress in endothelial progenitor cells. 2017 Mar 8
13 26931777 Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects. 2016 Nov 1
14 27719743 Effect of food on the oral bioavailability of the angiotensin receptor - neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects
. 2016 Dec 1
15 28164602 Effects of Angiotensin Inhibitor Valsartan on the Expression of the Angiotensin II 1 Receptor, Matrix Metalloproteinases -2 and -9 in Human Bladder Cancer Cell Lines. 2016 Aug 1 4
16 25591555 Valsartan decreases platelet activity and arterial thrombotic events in elderly patients with hypertension. 2015 Jan 20 2
17 26223916 Regulatory effects of AT₁R-TRAF6-MAPKs signaling on proliferation of intermittent hypoxia-induced human umbilical vein endothelial cells. 2015 Aug 1
18 24372930 Temporal association as a prerequisite factor of valsartan-induced lithium toxicity. 2014 Sep 1
19 24844704 Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. 2014 Sep 1
20 25109475 Valsartan independent of AT₁ receptor inhibits tissue factor, TLR-2 and -4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions. 2014 Oct 1
21 25346502 Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. 2014 Oct 1
22 25762441 Autoantibodies targeting AT1 receptor from patients with acute coronary syndrome upregulate proinflammatory cytokines expression in endothelial cells involving NF-κB pathway. 2014 1
23 22803969 Thermal behavior and phase identification of Valsartan by standard and temperature-modulated differential scanning calorimetry. 2013 Oct 2
24 23426512 [Angiotensin II activates large-conductance Ca(2+)-activated potassium channels in human mesenteric artery smooth muscle cells]. 2013 Feb 25 1
25 23553863 The effects of long-term valsartan treatment on skeletal muscle fatty acid handling in humans with impaired glucose metabolism. 2013 May 2
26 24070321 Azilsartan medoxomil in the treatment of hypertension: the definitive angiotensin receptor blocker? 2013 Nov 1
27 24219285 Angiotensin II downregulates ACE2-mediated enhancement of MMP-2 activity in human cardiofibroblasts. 2013 Dec 1
28 22045314 Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. 2012 Feb 1 2
29 22768174 Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. 2012 1
30 22884153 Different effects of telmisartan and valsartan on human aortic vascular smooth muscle cell proliferation. 2012 Jun 1
31 23038657 Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol. 2012 1
32 21315062 Interactions of the AT1 antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers. 2011 Jun 2
33 20399995 Pharmacokinetics and bioequivalence study of three oral formulations of valsartan 160 mg: a single-dose, randomized, open-label, three-period crossover comparison in healthy Indian male volunteers. 2010 Mar 1
34 20432929 [The effect of angiotensin II on phosphoinositide-3 kinase/Akt cascade in cultured fibroblasts derived from patients with hypertrophic scars]. 2010 Jan 1
35 20463030 Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. 2010 Jul 16 1
36 19256500 Antihypertensive drug valsartan in solution and at the AT1 receptor: conformational analysis, dynamic NMR spectroscopy, in silico docking, and molecular dynamics simulations. 2009 Mar 3
37 19307231 Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. 2009 Jun 1 7
38 19687742 Valsartan inhibits NPC cell line CNE-2 proliferation and invasion and promotes its sensitivity to radiation. 2009 Nov 1
39 19843489 Results of a single-center, single-dose, randomized-sequence, open-label, two-way crossover bioequivalence study of two formulations of valsartan 160-mg tablets in healthy volunteers under fasting conditions. 2009 Sep 1
40 19911855 Valsartan: more than a decade of experience. 2009 1
41 17878892 Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth. 2008 Feb 1
42 17322151 Effects of the angiotensin II type 1 receptor antagonist valsartan on the expression of superoxide dismutase in hypertensive patients. 2007 Mar 1
43 17393691 [Role of angiotensin II receptors in proliferation of fibroblast derived from human hypertrophic scars]. 2007 Jan 1
44 17875818 Novel regulatory effect of angiotensin II type 1 receptor-interacting molecule on vascular smooth muscle cells. 2007 Nov 1
45 17964282 Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. 2007 Dec 28 2
46 16713009 The angiotensin II receptor antagonist valsartan enhances lipoprotein lipase mass in preheparin serum in type 2 diabetes with hypertension. 2006 Dec 1
47 17086018 Angiotensin receptor blockade improves vascular compliance in healthy normotensive elderly individuals: results from a randomized double-blind placebo-controlled trial. 2006 Nov 1
48 15677497 Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress. 2005 Feb 1
49 15907144 Angiotensin antagonism in coronary artery disease: results after coronary revascularisation. 2005 1
50 16097371 Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells. 2005 Mar 1