Title : Valsartan, independently of AT1 receptor or PPARĪ³, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.

Pub. Date : 2012 Feb 1

PMID : 22045314






2 Functional Relationships(s)
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1 Very interestingly, this effect of valsartan was also observed in THP-1 cells treated with angiotensin II type 1 (AT1) siRNA or a peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist as well as macrophages from AT1a receptor-knockout mice. Valsartan angiotensin II receptor type 1 Homo sapiens
2 Very interestingly, this effect of valsartan was also observed in THP-1 cells treated with angiotensin II type 1 (AT1) siRNA or a peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist as well as macrophages from AT1a receptor-knockout mice. Valsartan angiotensin II receptor type 1 Homo sapiens