| 1 |
34336653 | Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy. | 2021 |
2 |
| 2 |
34778377 | The Effects of 5-Fluorouracil/Leucovorin Chemotherapy on Cognitive Function in Male Mice. | 2021 |
1 |
| 3 |
29258758 | Inhibition of thymidylate synthase affects neural tube development in mice. | 2018 Mar |
3 |
| 4 |
29374697 | Effective Timing of Surgical Resection of Colorectal Cancer Liver Metastases During Chemotherapy. | 2018 Feb |
1 |
| 5 |
26787540 | B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. | 2016 Jul |
1 |
| 6 |
26242737 | Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation. | 2015 Sep 18 |
2 |
| 7 |
24961587 | The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. | 2014 Jun 30 |
2 |
| 8 |
24040364 | 53BP1 sensitizes breast cancer cells to 5-fluorouracil. | 2013 |
1 |
| 9 |
22824673 | A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing. | 2012 Jul |
7 |
| 10 |
17549381 | Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. | 2007 Jul |
1 |
| 11 |
16855390 | A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes. | 2006 Aug |
1 |
| 12 |
16951168 | Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. | 2006 Sep 1 |
2 |
| 13 |
15930305 | A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. | 2005 Jun 1 |
1 |
| 14 |
16204693 | 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. | 2005 Oct 5 |
5 |
| 15 |
15025949 | Circadian expression of dihydropyrimidine dehydrogenase, thymidylate synthase, c-myc and p53 mRNA in mouse liver tissue. | 2004 Mar |
6 |
| 16 |
15224198 | Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU. | 2004 |
2 |
| 17 |
15475457 | Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase. | 2004 Oct 1 |
1 |
| 18 |
15509204 | Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma. | 2004 Nov |
3 |
| 19 |
15539941 | Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice. | 2004 Nov |
2 |
| 20 |
12691609 | Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil. | 2003 Mar 20 |
3 |
| 21 |
11816485 | [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]. | 2002 Jan |
1 |
| 22 |
12138245 | High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors. | 2002 |
1 |
| 23 |
10449194 | Modulation of fluorouracil antitumor activity by folic acid in a murine model system. | 1999 Sep 1 |
1 |
| 24 |
10489900 | The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo. | 1999 Jul |
2 |
| 25 |
9050858 | Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. | 1997 Mar 4 |
1 |
| 26 |
9620216 | 5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man. | 1997 |
1 |
| 27 |
8911125 | Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors. | 1996 Aug |
1 |
| 28 |
7577082 | Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice. | 1995 |
1 |
| 29 |
21597737 | Induction of resistance-proteins and oncoproteins in murine and human tumor-cell lines after irradiation. | 1995 May |
1 |
| 30 |
1378737 | Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue. Correlation of antitumor activity with dosage and FUra incorporation into RNA. | 1992 Jun 23 |
4 |
| 31 |
1379119 | Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination. | 1992 Aug 1 |
1 |
| 32 |
1516048 | Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. | 1992 Sep 15 |
5 |
| 33 |
1532671 | Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase. | 1992 Apr |
1 |
| 34 |
1580641 | [Significance of measuring 5-fluorouracil incorporated into RNA of tumor tissue as a parameter for the antitumor activity of 5-fluorouracil and its analogs]. | 1992 May |
1 |
| 35 |
1722409 | Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA. | 1991 Nov 27 |
2 |
| 36 |
2344373 | Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency. | 1990 Jun 1 |
1 |
| 37 |
2698593 | Effects of 5-fluorouracil on thymidylate synthase activity and development of bone marrow grafts in spleens of irradiated mice. | 1989 |
4 |
| 38 |
2971656 | Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. | 1988 Oct 5 |
1 |
| 39 |
3071089 | Effects of treatment of donor mice with phenylhydrazine and 5-fluorouracil on thymidylate synthase activity and growth of bone marrow grafts in spleens of irradiated recipients. | 1988 |
1 |
| 40 |
3395138 | [The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives]. | 1988 Jul |
6 |
| 41 |
2427493 | The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate synthase. | 1986 Jul |
2 |
| 42 |
3565050 | Increased thymidylate synthase activity in extracts of erythropoietic spleens of mice treated with 5-fluorouracil. | 1986 |
1 |
| 43 |
6608049 | Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil. | 1984 Mar |
1 |