Title : Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.

Pub. Date : 1997 Mar 4

PMID : 9050858






1 Functional Relationships(s)
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1 5-FU is a pyrimidine antimetabolite cytotoxin with multiple mechanisms of action, including inhibition of thymidylate synthase (TS), which gives rise to DNA damage, and incorporation into RNA. Fluorouracil thymidylate synthase Mus musculus