| 1 |
34648192 | Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine. | 2022 Feb |
1 |
| 2 |
35197312 | CYP2C19 plays a major role in the hepatic N-oxidation of cotinine. | 2022 Feb 23 |
1 |
| 3 |
30902024 | Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. | 2020 Feb |
2 |
| 4 |
30925039 | CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. | 2019 Jun 17 |
1 |
| 5 |
31239195 | Impact of flavin-containing monooxygenase 3 and CYP2C19 genotypes on plasma disposition and adverse effects of voriconazole administered orally in immunocompromised patients. | 2019 Dec |
1 |
| 6 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
1 |
| 7 |
28296334 | A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans. | 2017 Mar |
1 |
| 8 |
26375942 | Pharmacokinetic drug-drug interaction study between raltegravir and citalopram. | 2016 |
1 |
| 9 |
27185541 | Identification of in vitro and in vivo human metabolites of the new psychoactive substance nitracaine by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2016 Jul |
4 |
| 10 |
27457784 | Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans. | 2016 Oct |
1 |
| 11 |
25245581 | Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases. | 2015 Apr |
1 |
| 12 |
26138512 | High metabolic N-oxidation of voriconazole in a patient with refractory aspergillosis and CYP2C19*17/*17 genotype. | 2015 Oct |
1 |
| 13 |
26276083 | Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps. | 2015 Nov 4 |
1 |
| 14 |
26456786 | Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP). | 2015 Oct |
1 |
| 15 |
24428683 | Critical appraisal of 13C breath tests for microsomal liver function: aminopyrine revisited. | 2014 Apr |
1 |
| 16 |
25241292 | Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole. | 2014 Dec 1 |
1 |
| 17 |
23361230 | 2-methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques. | 2013 Apr |
1 |
| 18 |
23666577 | Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder. | 2013 Jun |
2 |
| 19 |
22349139 | In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine. | 2012 Jun |
1 |
| 20 |
22496396 | Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. | 2012 Jul |
1 |
| 21 |
22023129 | Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. | 2011 Nov |
1 |
| 22 |
20877236 | Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. | 2010 Sep 16 |
1 |
| 23 |
18725511 | The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers. | 2008 Nov |
1 |
| 24 |
17020955 | Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. | 2007 Jan |
1 |
| 25 |
17259447 | Enantiomeric metabolic interactions and stereoselective human methadone metabolism. | 2007 Apr |
2 |
| 26 |
17433262 | Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. | 2007 Jun 15 |
1 |
| 27 |
17576805 | Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. | 2007 Sep |
1 |
| 28 |
16802848 | Pharmacokinetic/pharmacodynamic profile of voriconazole. | 2006 |
1 |
| 29 |
15319333 | CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. | 2004 Sep |
1 |
| 30 |
12637241 | mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. | 2003 Mar |
1 |
| 31 |
12721102 | Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. | 2003 Apr |
1 |
| 32 |
12975335 | Pharmacokinetics of citalopram in relation to genetic polymorphism of CYP2C19. | 2003 Oct |
1 |
| 33 |
12012142 | The role of CYP2C19 in amitriptyline N-demethylation in Chinese subjects. | 2002 May |
2 |
| 34 |
12180536 | The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. | 2002 Jul |
2 |
| 35 |
11519155 | [Pharmacokinetics and drug interactions of antidepressive agents]. | 2001 Aug |
1 |
| 36 |
11606127 | Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. | 2001 Oct 25 |
1 |
| 37 |
10784435 | Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A. | 2000 Apr |
1 |
| 38 |
10199594 | Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. | 1999 Feb |
1 |
| 39 |
10460803 | Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. | 1999 Sep |
1 |
| 40 |
10510155 | Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes. | 1999 Sep |
2 |
| 41 |
10570024 | Role of human CYP2B6 in S-mephobarbital N-demethylation. | 1999 Dec |
1 |
| 42 |
9023308 | Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes. | 1997 Feb |
1 |
| 43 |
9084457 | Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4. | 1997 Mar |
1 |
| 44 |
9190854 | Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. | 1997 Jun |
5 |
| 45 |
9316174 | Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy. | 1997 Aug |
2 |
| 46 |
8712396 | Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. | 1996 Jan |
1 |