Guanine Nucleotides

eukaryotic translation initiation factor 2 subunit beta ; Homo sapiens







28 Article(s)
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1 35579296 Regulation and function of elF2B in neurological and metabolic disorders. 2022 Jun 30 1
2 34876589 eIF2B-capturing viral protein NSs suppresses the integrated stress response. 2021 Dec 7 1
3 29425030 eIF2B Mechanisms of Action and Regulation: A Thermodynamic View. 2018 Mar 6 2
4 29489452 The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes. 2018 Feb 28 1
5 26705305 Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity. 2016 Feb 2
6 19631657 Crystal structure of the alpha subunit of human translation initiation factor 2B. 2009 Oct 2 1
7 18631136 Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation. 2008 Aug 2
8 17512538 Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo. 2007 Jul 6 1
9 17526738 Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. 2007 Jul 3
10 16378743 Childhood ataxia with CNS hypomyelination/vanishing white matter disease--a common leukodystrophy caused by abnormal control of protein synthesis. 2006 May 1
11 16434554 Inhibition of mammalian translation initiation by volatile anesthetics. 2006 Jun 1
12 16582624 Localization of the translational guanine nucleotide exchange factor eIF2B: a common theme for GEFs? 2006 Apr 2
13 16990799 An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation. 2006 Oct 4 4
14 16157703 Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control. 2005 Sep 12 2
15 11726195 Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism? 2001 Dec 7 2
16 9446619 Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. 1998 Jan 30 2
17 9032257 Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. 1997 Mar 1
18 9328281 Wheat germ initiation factor 2 (WG x eIF2) decreases the inhibition in protein synthesis and eIF2B activity of reticulocyte lysates mediated by eIF2alpha phosphorylation. 1997 Oct 1 3
19 9345299 Catalysis of guanine nucleotide exchange on eIF-2 by eIF-2B: is it a sequential or substituted enzyme mechanism? 1997 Oct 9 2
20 8607853 The alpha-subunit of the mammalian guanine nucleotide-exchange factor eIF-2B is essential for catalytic activity in vitro. 1996 Mar 27 1
21 8887689 Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. 1996 Nov 1
22 8049218 Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange. 1994 Aug 9 2
23 8111971 Maturation hormone induced an increase in the translational activity of starfish oocytes coincident with the phosphorylation of the mRNA cap binding protein, eIF-4E, and the activation of several kinases. 1993 1
24 8336705 Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. 1993 Aug 2
25 8417348 GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae. 1993 Jan 1
26 2491852 Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein. 1989 Jan 5 1
27 3356694 The effect of Mg2+ and guanine nucleotide exchange factor on the binding of guanine nucleotides to eukaryotic initiation factor 2. 1988 Apr 25 2
28 6551177 Assembly and breakdown of mammalian protein synthesis initiation complexes: regulation by guanine nucleotides and by phosphorylation of initiation factor eIF-2. 1983 Feb 15 1