Title : Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism?

Pub. Date : 2001 Dec 7

PMID : 11726195






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism? Guanine Nucleotides eukaryotic translation initiation factor 2 subunit beta Homo sapiens
2 There are conflicting reports over the question of whether the displacement by GTP of GDP bound to eIF2 catalyzed by eIF2B follows a substituted enzyme mechanism, as is believed to be the case for other guanine nucleotide exchange factors, or is a sequential mechanism. Guanine Nucleotides eukaryotic translation initiation factor 2 subunit beta Homo sapiens