geldanamycin

N-methylpurine DNA glycosylase ; Homo sapiens







24 Article(s)
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1 30391349 Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment. 2019 Jan 5 1
2 29566599 Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells. 2018 Oct 1
3 27013225 Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer. 2016 1
4 24879994 SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG. 2014 Jul 18 2
5 25227799 Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer. 2014 1
6 23629654 Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation. 2013 Jun 14 1
7 23630365 Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo. 2013 Aug 1 1
8 17131314 Dimeric ansamycins--a new class of antitumor Hsp90 modulators with prolonged inhibitory activity. 2007 Feb 15 1
9 17230513 Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells. 2007 Apr 15 1
10 17363505 Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. 2007 Mar 1
11 17949452 Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia. 2007 Dec 1
12 16213582 The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level. 2006 May 1
13 16384610 Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. 2006 Apr 15 1
14 16544941 Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications. 2006 Mar 1
15 16634649 Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives. 2006 May 2 2
16 16860662 Inhibitors of the HSP90 molecular chaperone: current status. 2006 1
17 17108135 Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism. 2006 Nov 15 1
18 15804996 The geldanamycin derivative 17-AAG decreases VEGF secretion and leukemia growth support by trisomy 8 myelodysplastic syndrome bone marrow stromal cells. 2005 Mar 2
19 15853661 Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. 2005 1
20 20641498 68Ga-Trastuzumab F(ab’) fragment 2004 1
21 12617036 [Molecular chaperone HSP90 as a novel target for cancer chemotherapy]. 2003 Jan 1
22 12810654 Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. 2003 Jun 15 2
23 12036925 Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway. 2002 Jun 1 1
24 11358819 Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. 2001 May 15 1