Title : Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.

Pub. Date : 2001 May 15

PMID : 11358819






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 17-allylamino-17-demethoxygeldanamycin (17-AAG), a less toxic and less potent derivative of GA, inhibited the clonogenicity of glioma cells with IC(50) values of 13 nM in C6 cells and 35 nM in T98G cells. geldanamycin N-methylpurine DNA glycosylase Homo sapiens