Digoxin

ATP-binding cassette, sub-family B (MDR/TAP), member 1A ; Mus musculus







15 Article(s)
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Title
Pub. Year
#Total Relationships
1 35083640 Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers. 2022 Jan 26 1
2 26744253 Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice. 2016 Mar 2
3 25932627 Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport. 2015 1
4 24084745 P-glycoprotein ABCB1: a major player in drug handling by mammals. 2013 Oct 2
5 18812023 Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a-deficient and mdr1a-competent mice. 2008 Oct 1
6 17635670 Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood-brain barrier. 2007 Oct 1
7 12746221 Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. 2003 May 1
8 11959808 Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice. 2002 Apr 1
9 12128165 Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. 2002 Aug 2
10 11134265 P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro. 2001 Jan 1
11 10585223 Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice. 1999 Dec 4
12 9108099 Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. 1997 Apr 15 1
13 8647944 P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. 1996 Jun 1 3
14 8922756 Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. 1996 Nov 2
15 7560060 Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. 1995 Oct 5