Title : P-glycoprotein ABCB1: a major player in drug handling by mammals.

Pub. Date : 2013 Oct

PMID : 24084745






2 Functional Relationships(s)
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1 In the JCI papers that are the subject of this Hindsight, we showed that loss of Mdr1a (Abcb1a) had a profound effect on the tissue distribution and especially the brain accumulation of a range of drugs frequently used in humans, including dexamethasone, digoxin, cyclosporin A, ondansetron, domperidone, and loperamide. Digoxin ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus
2 In the JCI papers that are the subject of this Hindsight, we showed that loss of Mdr1a (Abcb1a) had a profound effect on the tissue distribution and especially the brain accumulation of a range of drugs frequently used in humans, including dexamethasone, digoxin, cyclosporin A, ondansetron, domperidone, and loperamide. Digoxin ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus