Styrene

cytochrome P450, family 2, subfamily f, polypeptide 2 ; Mus musculus







14 Article(s)
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Title
Pub. Year
#Total Relationships
1 32049351 Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway. 2020 May 1 1
2 32125430 Response to Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway. 2020 May 1 1
3 32452303 Relevance of mouse lung tumors to human risk assessment. 2020 Jul 3 1
4 29496518 Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern. 2018 Jun 1
5 28951217 Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures. 2017 Nov 15 1
6 28962520 Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. 2017 Oct 1 4
7 24320693 Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes. 2014 Jan 21 3
8 22041433 CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors. 2012 Feb 2
9 22386858 Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice. 2012 Apr 11 2
10 19589367 Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. 2009 Nov 1
11 15110085 Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide. 2004 May 2 1
12 12202046 Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites. 2002 Jun 4
13 11551533 The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans. 2001 Aug 31 2
14 10543021 Metabolism of styrene by mouse and rat isolated lung cells. 1999 Oct 1