Title : The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans.

Pub. Date : 2001 Aug 31

PMID : 11551533






2 Functional Relationships(s)
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1 Pretreatment of mice with 5-phenyl-1-pentyne, an inhibitor of both CYP2F2 and CYP2E1 completely prevented the development of a nasal lesion on exposure to styrene establishing that a metabolite of styrene, probably styrene oxide, is responsible for the observed nasal toxicity. Styrene cytochrome P450, family 2, subfamily f, polypeptide 2 Mus musculus
2 Pretreatment of mice with 5-phenyl-1-pentyne, an inhibitor of both CYP2F2 and CYP2E1 completely prevented the development of a nasal lesion on exposure to styrene establishing that a metabolite of styrene, probably styrene oxide, is responsible for the observed nasal toxicity. Styrene cytochrome P450, family 2, subfamily f, polypeptide 2 Mus musculus