| 1 |
35154362 | Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design. | 2022 |
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| 2 |
35214759 | Capturing a Crucial 'Disorder-to-Order Transition' at the Heart of the Coronavirus Molecular Pathology-Triggered by Highly Persistent, Interchangeable Salt-Bridges. | 2022 Feb 16 |
2 |
| 3 |
35432786 | Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2. | 2022 |
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| 4 |
33732412 | The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. | 2021 Mar 11 |
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| 5 |
33787218 | Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry. | 2021 Apr 21 |
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| 6 |
34200372 | ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin. | 2021 Jun 7 |
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| 7 |
34415722 | OFF-State-Specific Inhibition of the Proprotein Convertase Furin. | 2021 Sep 17 |
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| 8 |
34960779 | Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket. | 2021 Dec 14 |
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| 9 |
31932825 | Characterization of the furin cleavage motif for HIV-1 trimeric envelope glycoprotein by intact LC-MS analysis. | 2020 Mar 2 |
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| 10 |
32995772 | In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein. | 2020 Sep 23 |
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| 11 |
33037310 | The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV. | 2020 Oct 9 |
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| 12 |
30409181 | Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris. | 2018 Nov 8 |
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| 13 |
28000813 | Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells. | 2017 Jan 17 |
2 |
| 14 |
24079887 | Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F. | 2013 Oct 29 |
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| 15 |
21147780 | In vivo evidence that furin from hepatocytes inactivates PCSK9. | 2011 Feb 11 |
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| 16 |
21204952 | Bordetella dermonecrotic toxin binds to target cells via the N-terminal 30 amino acids. | 2011 Mar |
2 |
| 17 |
21813706 | Modification of the trypsin cleavage site of rotavirus VP4 to a furin-sensitive form does not enhance replication efficiency. | 2011 Dec |
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| 18 |
19352504 | Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site. | 2009 |
2 |
| 19 |
17989726 | Correlation between SPINK5 gene mutations and clinical manifestations in Netherton syndrome patients. | 2008 May |
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| 20 |
18712106 | [Furin and its biological role]. | 2007 Nov-Dec |
5 |
| 21 |
16601116 | Identification of a pH sensor in the furin propeptide that regulates enzyme activation. | 2006 Jun 9 |
2 |
| 22 |
15596135 | Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. | 2005 Jan 21 |
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| 23 |
16289022 | ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms. | 2005 Dec 1 |
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| 24 |
14597616 | Bordetella dermonecrotic toxin undergoes proteolytic processing to be translocated from a dynamin-related endosome into the cytoplasm in an acidification-independent manner. | 2004 Jan 23 |
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| 25 |
15371436 | Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection. | 2004 Nov 19 |
7 |
| 26 |
12514189 | Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. | 2003 Mar 14 |
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| 27 |
12691605 | Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. | 2003 Jul 15 |
3 |
| 28 |
12794637 | The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. | 2003 Jul |
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| 29 |
12832612 | Optimization of protease-inhibitor interactions by randomizing adventitious contacts. | 2003 Jul 8 |
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| 30 |
11799113 | The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. | 2002 Apr 12 |
7 |
| 31 |
11861638 | Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. | 2002 May 10 |
2 |
| 32 |
12487813 | Processing of the HTLV-II envelope precursor glycoprotein gp63 by furin is essential for cell fusion activity. | 2002 Nov 20 |
8 |
| 33 |
11479287 | The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin. | 2001 Oct 19 |
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| 34 |
10620501 | Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxins. | 2000 Jan 15 |
2 |
| 35 |
11106495 | Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin. | 2000 Dec 12 |
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| 36 |
10217293 | Specificity of the dynorphin-processing endoprotease: comparison with prohormone convertases. | 1999 May |
2 |
| 37 |
10493908 | Enzymic characterization in vitro of recombinant proprotein convertase PC4. | 1999 Oct 1 |
2 |
| 38 |
9442015 | Inhibition of soluble recombinant furin by human proteinase inhibitor 8. | 1998 Jan 23 |
2 |
| 39 |
9535830 | In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor. | 1998 Apr 10 |
5 |
| 40 |
9557754 | Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin. | 1998 May |
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| 41 |
9130696 | Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. | 1997 Apr 1 |
2 |
| 42 |
9266488 | Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1. | 1997 Jun |
2 |
| 43 |
8983022 | Production of recombinant proteins in Chinese hamster ovary cells overexpressing the subtilisin-like proprotein converting enzyme furin. | 1996 |
3 |
| 44 |
7499343 | Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain. | 1995 Nov 24 |
3 |
| 45 |
7592877 | A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation. | 1995 Nov 3 |
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| 46 |
7619075 | Direct role of furin in mammalian prosomatostatin processing. | 1995 Jul 1 |
3 |
| 47 |
7642593 | Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor. | 1995 Aug 18 |
2 |
| 48 |
7741698 | An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor. | 1995 May 1 |
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| 49 |
7852339 | Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum. | 1995 Feb 10 |
4 |
| 50 |
7508380 | Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. | 1994 Jan 1 |
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