Tyrosine

Cbl proto-oncogene ; Homo sapiens







222 Article(s)
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51 18404481 The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes. 2006 Jun 1
52 15650401 Life and death decisions: ceramide generation and EGF receptor trafficking are modulated by oxidative stress. 2005 Jan-Feb 2
53 15677445 Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase. 2005 Apr 8 2
54 15708858 c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. 2005 Apr 22 1
55 15737992 Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. 2005 May 13 2
56 15878338 The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules. 2005 May 15 1
57 15892963 Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. 2005 Jun 5 1
58 15922744 c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1. 2005 Jul 1 3
59 16168963 Contrasting effects of insulin and cellular differentiation on expression of the novel insulin receptor substrate APS in skeletal muscle. 2005 Nov 1 1
60 14551058 Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. 2004 Feb 2
61 15004239 Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. 2004 May 1
62 15094368 Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils. 2004 May 14 1
63 15117950 Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. 2004 Jul 2 9
64 15123609 A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. 2004 Jul 9 1
65 15161351 UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain. 2004 Jun 1
66 15169881 Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. 2004 Jun 1
67 15226403 ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. 2004 Jul 1 1
68 15304502 Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl. 2004 Oct 15 1
69 15337528 c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination. 2004 Nov 2
70 15456872 Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. 2004 Oct 1
71 15581361 Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes. 2004 Dec 14 2
72 12435267 Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. 2003 Mar 1 1
73 12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. 2003 Feb 18 1
74 12604776 Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors. 2003 Mar 4 1
75 12696071 Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia. 2003 Jun 1
76 12717426 70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism. 2003 Apr 24 1
77 12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function. 2003 Aug 29 4
78 12842890 The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. 2003 Sep 19 2
79 12881521 Cbl-mediated ubiquitinylation and negative regulation of Vav. 2003 Oct 3 4
80 12941616 A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes. 2003 Sep 10 2
81 14511371 Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. 2003 Oct 1
82 14523017 CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor. 2003 Dec 12 1
83 14530346 Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells. 2003 Oct 15 2
84 14585370 Selectins and anti-CD15 (Lewis x/a) antibodies transmit activation signals in Hodgkin's lymphoma-derived cell lines. 2003 Nov 2
85 14604282 Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppression of autonomous cell growth but no effect on decreased adhesive property and morphological changes. 2003 Oct 1
86 14640702 Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes. 2003 Dec 9 1
87 11777909 c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. 2002 Mar 8 1
88 11792427 Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation. 2002 Jan 2
89 11850825 C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. 2002 Feb 7 2
90 11970992 The Src family kinase Fyn mediates signals induced by TCR antagonists. 2002 May 1 1
91 11997436 FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. 2002 May 14 1
92 12024036 Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. 2002 Jun 1
93 12094251 Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells. 2002 Jul 1
94 12244174 c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. 2002 Oct 1 2
95 11067845 The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. 2001 Feb 16 6
96 11133830 The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation. 2001 Jan 2
97 11149930 Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. 2001 Jan 8 1
98 11157475 SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways. 2001 Feb 1 1
99 11260061 Platelet activation via the collagen receptor GPVI is not altered in platelets from chronic myeloid leukaemia patients despite the presence of the constitutively phosphorylated adapter protein CrkL. 2001 Mar 1
100 11262396 Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. 2001 Jun 15 1