Phenobarbital

cytochrome P450, family 1, subfamily a, polypeptide 1 ; Rattus norvegicus







63 Article(s)
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1 30842367 Effect of the metabolic capacity in rat liver S9 on the positive results of in vitro micronucleus tests. 2019 1
2 24025784 Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. 2013 1
3 20551240 Liverbeads: a practical and relevant in vitro model for gene induction investigations. 2010 Sep 1
4 18798224 Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response. 2009 Mar 1
5 16581946 Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants. 2006 Jul 1
6 16597362 Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats. 2006 Apr 1
7 15744758 Effect of beta-naphthoflavone and phenobarbital on the nephrotoxicity of chlorotrifluoroethylene and 1,1-dichloro-2,2-difluoroethylene in the rat. 2005 Mar-Apr 1
8 15946133 Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes. 2005 Jun 1
9 15607757 An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. 2004 Dec 30 1
10 12028663 Metabolite of 2,2',4',5-tetrabromobiphenyl, 3-methylsulphonyl-2,2',4',5-tetrabromobiphenyl, a potent inducer of CYP2B1/2 in rat. 2002 Apr 2
11 11322933 Effects of epidermal growth factor on CYP inducibility by xenobiotics, DNA replication, and caspase activations in collagen I gel sandwich cultures of rat hepatocytes. 2001 May 15 1
12 10772642 Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. 2000 May 1
13 10096772 Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. 1999 Feb 26 2
14 10528997 The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. 1999 Sep 30 1
15 10547882 [Change in the rat liver microsomal monooxygenase system upon induction with phenobarbital in acute pancreatitis]. 1999 Jul-Aug 1
16 8080435 CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. 1994 Aug 17 2
17 8209390 Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes. 1994 Jun 1
18 20693085 Quantification of CYP1A1 and 2B1/2 in rat hepatocytes cultured in microwells by immunological methods. 1994 Dec 1
19 7692844 Characterization of Clara and type II cells isolated from rat lung by fluorescence-activated flow cytometry. 1993 Oct 1 1
20 8442654 Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture. 1993 Feb 15 1
21 1349513 Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats. 1992 Apr 1
22 1800893 The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays. 1991 Nov 1
23 2097280 [Effects of age and selected inductors of aromatic hydrocarbon hydroxylase (AHH) activity in the rat liver]. 1990 1
24 2510947 The phenobarbital-type induction of rat liver microsomal monooxygenases by perfluorodecalin. 1989 2
25 2536534 Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. 1989 Feb 1 1
26 2787638 Dependence of the induction of cytochrome P-450 by phenobarbital in primary cultures of adult rat hepatocytes on the composition of the culture medium. 1989 Jul 15 1
27 2815336 [The effect of separate and consecutive administration of cytochrome P-450 inducers to rats on the localization of various isoforms of the enzyme in liver lobe cells]. 1989 Jul 3
28 2815832 Induction of cytochrome P-450 isozymes by chromanamine derivatives in rat liver. 1989 Aug 1
29 2846197 Transplacental induction of cytochromes P-450IA1 and P-450IA2 by polycyclic aromatic carcinogens: TCDD-binding protein level as the rate-limiting step. 1988 Nov 1
30 3130800 The expression and metabolic activity of cytochrome P-450 isozymes in control and phenobarbital-induced primary cultures of rat hepatocytes. 1988 May 15 3
31 3145631 Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls. 1988 Dec 30 1
32 3109500 [The level and activity of molecular forms of monooxygenase P-450b and P-450c during their separate and consecutive induction in the liver]. 1987 Apr 1
33 3299136 Immunohistochemical localization of cytochrome P-450 in rat brain. 1987 Mar 1
34 3545456 Immunological identification and effects of 3-methylcholanthrene and phenobarbital on rat pulmonary cytochrome P-450. 1987 Apr 1 2
35 3566772 Effect of excessive intake of ascorbic acid on hepatic and extra-hepatic phase I and phase II drug metabolism in rat. 1987 Jan 2
36 3675602 Synergy of phenobarbital and 3-methylcholanthrene in "superinduction" of cytochrome P-450c mRNA but not enzyme activity. 1987 Oct 15 3
37 3825173 Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study. 1987 Jan 1
38 3715917 Regioselective inhibition of benzo(a)pyrene metabolism by corticosterone in comparison with metyrapone and alpha-naphthoflavone. 1986 Apr 2
39 2985574 Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. 1985 Apr 25 2
40 3001883 Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury. 1985 Oct 2
41 3877941 Specificity of medicarpin and related isoflavonoids in inhibition of rat hepatic mixed function oxidase activity. 1985 2
42 6096035 Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells. 1984 Dec 3
43 6334605 Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital. 1984 Dec 17 1
44 6436235 Hepatic mitochondrial cytochrome P-450 system. Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene. 1984 Oct 25 1
45 6465891 Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation. 1984 Aug 1 1
46 6494651 Metabolic hydrolysis of isoniazid by subcellular fractions of rat liver. 1984 Sep 1 1
47 6825202 The binding to oxidised cytochromes P-450 and inhibition of mixed-function oxidases by aryl-substituted benzimidazoles and related compounds. 1983 Mar 1
48 6838626 Studies on metabolism and toxicity of styrene--VI. Regioselectivity in glutathione S-conjugation and hydrolysis of racemic, R- and S-phenyloxiranes in rat liver. 1983 Mar 1 1
49 6860371 Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation. 1983 May 1 1
50 6885729 Phenobarbital- and 3-methylcholanthrene-induced synthesis of two different molecular species of microsomal cytochrome P-450 in rat liver. 1983 May 1