Title : [The effect of separate and consecutive administration of cytochrome P-450 inducers to rats on the localization of various isoforms of the enzyme in liver lobe cells].

Pub. Date : 1989 Jul

PMID : 2815336






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 By means of immunohistochemical methods a study of the liver intralobular localization of cytochromes P-450b(+e) and P-450c(+d) has been carried out after separate and consecutive treatment of rats with phenobarbital (PB) and 3-methylcholanthrene (MC). Phenobarbital cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus
2 The consecutive treatment with PB and MC is accompanied by the localization of P-450c only in cells of the periportal region of the lobule. Phenobarbital cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus
3 PB-treatment of rats after preliminary MC-injection also results in the periportal localization of P-450c, and a small quantity of P-450b is localized in hepatocytes of the centrilobular region. Phenobarbital cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus