| 1 |
35409102 | Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. | 2022 Mar 29 |
1 |
| 2 |
32615946 | Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism. | 2020 Jul 2 |
1 |
| 3 |
33316932 | Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. | 2020 Dec 9 |
2 |
| 4 |
31792175 | Repurposing dichloroacetate for the treatment of women with endometriosis. | 2019 Dec 17 |
2 |
| 5 |
28595656 | ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells. | 2017 Jun 8 |
1 |
| 6 |
29070699 | Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients. | 2017 Oct 25 |
2 |
| 7 |
29535790 | A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents. | 2017 Summer |
6 |
| 8 |
25536473 | Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. | 2015 Feb 1 |
4 |
| 9 |
25644430 | SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. | 2015 |
1 |
| 10 |
25795215 | Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study. | 2015 Aug |
1 |
| 11 |
25973318 | DCA promotes progression of neuroblastoma tumors in nude mice. | 2015 |
2 |
| 12 |
25995437 | The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. | 2015 Aug |
2 |
| 13 |
26045167 | IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. | 2015 Aug 1 |
2 |
| 14 |
25320679 | Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes. | 2014 |
2 |
| 15 |
23247844 | FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. | 2013 Mar |
1 |
| 16 |
23662191 | Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. | 2013 Jan |
1 |
| 17 |
22508045 | Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy? | 2012 |
4 |
| 18 |
21346867 | Development of a less toxic dichloroacetate analogue by docking and descriptor analysis. | 2010 Jul 6 |
7 |
| 19 |
19694452 | Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation. | 2009 Oct |
5 |
| 20 |
18206410 | A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate. | 2008 Apr |
4 |
| 21 |
12067850 | Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. | 2002 Jul |
2 |
| 22 |
11001755 | Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. | 2000 Oct |
3 |
| 23 |
10409123 | Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise. | 1999 Jul |
2 |
| 24 |
10449128 | Dichloroacetate stabilizes the mutant E1alpha subunit in pyruvate dehydrogenase deficiency. | 1999 Aug 11 |
11 |
| 25 |
10562618 | Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. | 1999 Nov |
1 |
| 26 |
15992085 | Dichloroacetate and cerebral ischaemia therapeutics. | 1999 Apr |
4 |
| 27 |
9514176 | Effects of dichloroacetate on mechanical recovery and oxidation of physiologic substrates after ischemia and reperfusion in the isolated heart. | 1998 Mar |
3 |
| 28 |
9530159 | Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate. | 1998 Mar |
2 |
| 29 |
9818855 | Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetate. | 1998 Nov |
9 |
| 30 |
9322450 | Oxygen metabolism during liver transplantation: the effect of dichloroacetate. | 1997 Oct |
6 |
| 31 |
9450646 | TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function. | 1997 Dec |
2 |
| 32 |
18623591 | Dichloroacetate increases cell and antibody yields in batch cultures of a hybridoma cell line. | 1996 Feb 20 |
4 |
| 33 |
8142598 | Cachectin/TNF-mediated lactate production in cultured myocytes is linked to activation of a futile substrate cycle. | 1993 Sep |
4 |
| 34 |
1590531 | The Rett syndrome and CSF lactic acid patterns. | 1992 Jan |
4 |
| 35 |
1600837 | Dichloroacetate. | 1992 Jun |
1 |
| 36 |
2723637 | Effect of dichloroacetate on regional energy metabolites and pyruvate dehydrogenase activity during ischemia and reperfusion in gerbil brain. | 1989 Jun |
6 |
| 37 |
2751069 | Effect of sodium dichloroacetate on human pyruvate metabolism. | 1989 |
1 |
| 38 |
3440441 | Congenital lactic acidosis. | 1987 |
1 |