Pub. Date : 2015 Feb 1
PMID : 25536473
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. | Dichloroacetic Acid | pyruvate dehydrogenase phosphatase catalytic subunit 1 | Homo sapiens |
| 2 | Dichloroacetate (DCA) is a small molecule that inhibits pyruvate dehydrogenase kinase (PDK) to constrain the aerobic glycolytic pathway observed in many cancer cells and effectively kill them with limited cytotoxicity on normal cells. | Dichloroacetic Acid | pyruvate dehydrogenase phosphatase catalytic subunit 1 | Homo sapiens |
| 3 | Dichloroacetate (DCA) is a small molecule that inhibits pyruvate dehydrogenase kinase (PDK) to constrain the aerobic glycolytic pathway observed in many cancer cells and effectively kill them with limited cytotoxicity on normal cells. | Dichloroacetic Acid | pyruvate dehydrogenase phosphatase catalytic subunit 1 | Homo sapiens |
| 4 | We show evidence of differential regulation in PDH phosphorylation between different human CRC cells leading to differences in mitochondrial activity following DCA exposure. | Dichloroacetic Acid | pyruvate dehydrogenase phosphatase catalytic subunit 1 | Homo sapiens |