polypyrimidine

U2 small nuclear RNA auxiliary factor 2 ; Homo sapiens







49 Article(s)
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1 35524551 Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. 2022 May 20 2
2 34868124 Phylogenetic Analysis of the Plant U2 snRNP Auxiliary Factor Large Subunit A Gene Family in Response to Developmental Cues and Environmental Stimuli. 2021 1
3 32343311 A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation. 2020 Jun 4 1
4 33020180 Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. 2020 Dec 11 2
5 33317029 U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing. 2020 Dec 9 1
6 28850223 Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. 2017 Sep 12 1
7 26896798 αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. 2016 Mar 18 1
8 26952537 An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. 2016 Mar 8 1
9 27799531 Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift. 2016 Nov 15 1
10 26216990 Splicing inhibition of U2AF65 leads to alternative exon skipping. 2015 Aug 11 2
11 24150945 Functional characterization of the common c.-32-13T>G mutation of GAA gene: identification of potential therapeutic agents. 2014 Jan 1
12 24734879 Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study. 2014 May 14 1
13 24793692 How slow RNA polymerase II elongation favors alternative exon skipping. 2014 May 22 1
14 23283975 Basal splicing factors regulate the stability of mature mRNAs in trypanosomes. 2013 Feb 15 1
15 23376934 U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. 2013 Apr 1 1
16 22144099 Promiscuity in protein-RNA interactions: conformational ensembles facilitate molecular recognition in the spliceosome: conformational diversity in U2AF⁶⁵ facilitates binding to diverse RNA sequences. 2012 Mar 1
17 22702716 A Broad range of conformations contribute to the solution ensemble of the essential splicing factor U2AF(65). 2012 Jul 3 1
18 22730292 YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts. 2012 Sep 1 1
19 23017209 RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract. 2012 Nov 2 2
20 21071404 An SF1 affinity model to identify branch point sequences in human introns. 2011 Mar 1
21 21753750 Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. 2011 Jul 13 2
22 19144709 Roles of polypyrimidine tract binding proteins in major immediate-early gene expression and viral replication of human cytomegalovirus. 2009 Apr 1
23 18067274 Alternative modes of binding by U2AF65 at the polypyrimidine tract. 2008 Jan 8 2
24 18842594 Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65. 2008 Nov 28 1
25 17188295 Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif. 2007 Feb 23 2
26 16403634 Novel modes of splicing repression by PTB. 2006 Feb 1
27 16818232 Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65. 2006 Jul 7 2
28 16906767 The SF3b155 N-terminal domain is a scaffold important for splicing. 2006 Aug 22 1
29 16940179 In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site. 2006 Nov 2
30 16982681 The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunit. 2006 Dec 2
31 16043505 FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35. 2005 Aug 1
32 14730023 The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. 2004 Feb 1
33 14612416 Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. 2003 Dec 2
34 11438677 Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complex. 2001 Aug 1
35 11575921 SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain. 2001 Sep 28 1
36 10864047 Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal. 2000 Jun 1
37 10049361 Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. 1999 Feb 15 1
38 10449418 Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)). 1999 Aug 16 1
39 10567551 Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). 1999 Dec 2
40 10617206 Functional recognition of the 3' splice site AG by the splicing factor U2AF35. 1999 Dec 16 1
41 9512519 A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. 1998 Mar 15 2
42 9242493 U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. 1997 Jul 15 1
43 8713106 Biochemical properties of a novel U2AF65 protein isoform generated by alternative RNA splicing. 1996 Jul 25 2
44 8781232 Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected]. 1996 Sep 20 3
45 7493318 Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein. 1995 Jun 1
46 7761834 Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. 1995 May 26 1
47 8643376 Splicing of two weak 3' splice sites from the adenovirus major late region is enhanced in nuclear extracts from adenovirus infected cells. 1995 1
48 8206372 A single point mutation results in A allele-specific exon skipping in the bovine alpha s1-casein mRNA. 1994 Jun 10 2
49 1388271 Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. 1992 Sep 15 1