| 1 |
34635508 | Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma. | 2022 Jan |
1 |
| 2 |
33307066 | Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. | 2021 Jan 15 |
8 |
| 3 |
34900592 | Complex response to physiological and drug-induced hepatic heme demand in monoallelic ALAS1 mice. | 2021 Dec |
3 |
| 4 |
30639045 | Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. | 2019 Nov |
1 |
| 5 |
29364890 | 5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice. | 2018 |
2 |
| 6 |
28213091 | Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. | 2017 Apr 15 |
2 |
| 7 |
27438535 | Chronic Treatment with Isoniazid Causes Protoporphyrin IX Accumulation in Mouse Liver. | 2016 Aug 15 |
2 |
| 8 |
25315005 | Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. | 2015 Apr |
4 |
| 9 |
24718052 | Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death. | 2014 |
2 |
| 10 |
21044876 | Egr-1 regulates the transcriptional repression of mouse δ-aminolevulinic acid synthase 1 by heme. | 2011 Feb 1 |
13 |
| 11 |
19917609 | Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase. | 2010 Jan 29 |
1 |
| 12 |
20015225 | Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse. | 2010 Jan |
3 |
| 13 |
20427485 | Regulation of adipogenesis by natural and synthetic REV-ERB ligands. | 2010 Jul |
5 |
| 14 |
19245819 | Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. | 2009 May 1 |
1 |
| 15 |
19562746 | Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity. | 2009 Sep |
2 |
| 16 |
20018698 | PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. | 2009 Dec 29 |
1 |
| 17 |
18929534 | B2 SINE retrotransposon causes polymorphic expression of mouse 5-aminolevulinic acid synthase 1 gene. | 2008 Dec 12 |
2 |
| 18 |
16567402 | Up-regulation of heme biosynthesis during differentiation of Neuro2a cells. | 2006 Mar |
2 |
| 19 |
15793285 | Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool. | 2005 Apr |
1 |
| 20 |
16122419 | Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. | 2005 Aug 26 |
1 |
| 21 |
12573483 | Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR. | 2003 Feb 17 |
4 |
| 22 |
12881517 | Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. | 2003 Oct 10 |
1 |
| 23 |
11566198 | The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase. | 2001 Sep 14 |
2 |
| 24 |
11368326 | Multiple regulatory steps in erythroid heme biosynthesis. | 2000 Dec 15 |
3 |
| 25 |
10212188 | Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release. | 1999 Apr 30 |
2 |
| 26 |
9521672 | Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor. | 1998 Mar 10 |
2 |
| 27 |
1894633 | Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA. | 1991 Sep 15 |
1 |
| 28 |
2780318 | Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites. | 1989 Sep 12 |
1 |
| 29 |
3442377 | Effects of chlorinated organics on intermediates in the heme pathway and on uroporphyrinogen decarboxylase. | 1987 |
1 |