Pub. Date : 2011 Feb 1
PMID : 21044876
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 2 | delta-Aminolevulinic acid synthase 1 (ALAS1) is the first and rate-limiting enzyme in the heme biosynthesis. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 3 | delta-Aminolevulinic acid synthase 1 (ALAS1) is the first and rate-limiting enzyme in the heme biosynthesis. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 4 | It has been well known that heme exerts a negative feedback control over the transcription of ALAS1 gene to maintain intracellular heme at appropriate level. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 5 | It has been well known that heme exerts a negative feedback control over the transcription of ALAS1 gene to maintain intracellular heme at appropriate level. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 6 | To clarify the mechanisms by which heme regulates the expression of ALAS1, we examined the promoter activity of the gene and identified the heme-responsive element (HRE) located in the proximal promoter of the mouse ALAS1 gene. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 7 | To clarify the mechanisms by which heme regulates the expression of ALAS1, we examined the promoter activity of the gene and identified the heme-responsive element (HRE) located in the proximal promoter of the mouse ALAS1 gene. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 8 | To clarify the mechanisms by which heme regulates the expression of ALAS1, we examined the promoter activity of the gene and identified the heme-responsive element (HRE) located in the proximal promoter of the mouse ALAS1 gene. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 9 | To clarify the mechanisms by which heme regulates the expression of ALAS1, we examined the promoter activity of the gene and identified the heme-responsive element (HRE) located in the proximal promoter of the mouse ALAS1 gene. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 10 | Reporter and EMSA assays revealed the sequence (GCGGGGGCG), as the site of repression by heme, at -301/-293bp of the ALAS1 promoter. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 11 | Subsequently, EMSA and ChIP assays showed that a transcription factor, early growth response 1 (Egr-1) and its major corepressors, NAB1 and NAB2 were found to bind to the ALAS1-HRE, and these bindings increased dependent on the level of intracellular heme. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 12 | These results suggest that Egr-1-NABs complex is involved in the regulation of the transcription of ALAS1 by heme, leading to the regulation of the heme biosynthesis. | Heme | aminolevulinic acid synthase 1 | Mus musculus |
| 13 | These results suggest that Egr-1-NABs complex is involved in the regulation of the transcription of ALAS1 by heme, leading to the regulation of the heme biosynthesis. | Heme | aminolevulinic acid synthase 1 | Mus musculus |