| 1 |
28846301 | Zileuton | 2022 Jan |
2 |
| 2 |
34801853 | Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms. | 2022 Jan |
1 |
| 3 |
35251467 | 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. | 2022 |
1 |
| 4 |
34116165 | Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells. | 2021 Oct |
1 |
| 5 |
31785932 | Pharmaceutical analysis combined with in-silico therapeutic and toxicological profiling on zileuton and its impurities to assist in modern drug discovery. | 2020 Feb 5 |
2 |
| 6 |
31841698 | Zileuton use and phenotypic features in asthma. | 2020 Feb |
1 |
| 7 |
32795513 | High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate IK(Ca) but suppress IK(DR) and IK(M) independently of 5-lipoxygenase inhibition. | 2020 Nov 15 |
2 |
| 8 |
32799052 | A cheminformatic study on chemical space characterization and diversity analysis of 5-LOX inhibitors. | 2020 Nov |
2 |
| 9 |
31331653 | 5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach. | 2019 Sep 1 |
1 |
| 10 |
29414995 | The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study. | 2018 |
1 |
| 11 |
29421656 | Inhibition of 5-lipoxygenase represses neutrophils activation and activates apoptosis in pancreatic tissues during acute necrotizing pancreatitis. | 2018 Mar 25 |
3 |
| 12 |
29953727 | Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship. | 2018 Nov |
2 |
| 13 |
30199704 | Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase. | 2018 Oct 5 |
1 |
| 14 |
30321850 | QSAR classification-based virtual screening followed by molecular docking studies for identification of potential inhibitors of 5-lipoxygenase. | 2018 Dec |
1 |
| 15 |
30410359 | Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway. | 2018 |
1 |
| 16 |
28680195 | New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis. | 2017 |
1 |
| 17 |
29290980 | Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin. | 2017 Dec 5 |
2 |
| 18 |
27599517 | 5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages. | 2016 Jul |
3 |
| 19 |
24662827 | Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. | 2015 Mar 5 |
1 |
| 20 |
25483364 | Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. | 2015 Feb |
3 |
| 21 |
25597508 | Management of severe acne. | 2015 Jul |
1 |
| 22 |
26412995 | Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. | 2015 Fall |
1 |
| 23 |
24525097 | High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species. | 2014 May |
2 |
| 24 |
23505486 | Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton. | 2013 |
3 |
| 25 |
24026253 | Systems pharmacology models can be used to understand complex pharmacokinetic-pharmacodynamic behavior: an example using 5-lipoxygenase inhibitors. | 2013 Sep 11 |
1 |
| 26 |
24029553 | Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. | 2013 Oct 15 |
2 |
| 27 |
22680930 | Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors. | 2012 |
1 |
| 28 |
23245693 | The diversity of Stemona stilbenoids as a result of storage and fungal infection. | 2012 Dec 28 |
1 |
| 29 |
21299475 | Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. | 2011 Feb |
1 |
| 30 |
21833474 | 5-Lipoxygenase contributes to the progression of hepatocellular carcinoma. | 2011 Nov-Dec |
2 |
| 31 |
20880396 | The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. | 2010 Oct |
4 |
| 32 |
19214143 | 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. | 2009 Mar |
2 |
| 33 |
19280518 | 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton. | 2009 Mar |
1 |
| 34 |
20436887 | Zileuton, a new efficient and safe systemic anti-acne drug. | 2009 May |
1 |
| 35 |
18927292 | Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. | 2008 Oct 15 |
1 |
| 36 |
21437139 | Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review. | 2008 Dec 9 |
1 |
| 37 |
17258303 | Assessment of in vivo 5-lipoxygenase activity by analysis of leukotriene B4 in saliva: effects of treatment with zileuton. | 2007 May |
1 |
| 38 |
17394438 | Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease. | 2007 Apr |
2 |
| 39 |
17722971 | Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma. | 2007 |
1 |
| 40 |
17982097 | FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independent. | 2007 Nov 15 |
1 |
| 41 |
16681569 | Is there a role for antileukotrienes in urticaria? | 2006 May |
1 |
| 42 |
15604543 | Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production. | 2005 |
2 |
| 43 |
15705997 | The effects of a 5-lipoxygenase inhibitor on acute mountain sickness and urinary leukotriene e4 after ascent to high altitude. | 2005 Feb |
1 |
| 44 |
15475461 | Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. | 2004 Oct 1 |
1 |
| 45 |
15501964 | Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide. | 2004 Oct 15 |
1 |
| 46 |
12735786 | Benefit-risk assessment of antileukotrienes in the management of asthma. | 2003 |
1 |
| 47 |
12756111 | A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. | 2003 May |
1 |
| 48 |
12923360 | The role of leukotriene inhibitors in patients with paranasal sinus disease. | 2003 Jun |
1 |
| 49 |
12949886 | Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. | 2003 Sep |
1 |
| 50 |
14570767 | Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. | 2003 Nov |
2 |