Title : High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species.

Pub. Date : 2014 May

PMID : 24525097






2 Functional Relationships(s)
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1 The cellular expression of 5-lipoxygenase, however, was up-regulated by 200 muM genistein and the addition of 5-lipoxygenase inhibitor (Zileuton) decreased genistein-induced intracellular ROS level, close to that from the addition of the ROS scavenger, N-acetylcysteine. zileuton arachidonate 5-lipoxygenase Homo sapiens
2 The cellular expression of 5-lipoxygenase, however, was up-regulated by 200 muM genistein and the addition of 5-lipoxygenase inhibitor (Zileuton) decreased genistein-induced intracellular ROS level, close to that from the addition of the ROS scavenger, N-acetylcysteine. zileuton arachidonate 5-lipoxygenase Homo sapiens