Serine

⇄

homeodomain interacting protein kinase 2 ; Homo sapiens







42 Article(s)
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1 35522151 Knockdown of HIPK2 attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts. 2022 May 6 2
2 31130327 Multiple pathways for natural product treatment of Parkinson's disease: A mini review. 2019 Jul 1
3 31284535 HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission. 2019 Jul 5 1
4 27901482 Hyperglycemia triggers HIPK2 protein degradation. 2017 Jan 3 1
5 26113041 HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism. 2016 Jan 1
6 25630557 Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK). 2015 Jan 29 1
7 25659434 Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity. 2015 Mar 27 1
8 25944899 The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. 2015 Jul 3 1
9 26247811 Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2. 2015 Nov 1
10 24951648 Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility. 2014 Jun 20 1
11 25313037 XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313. 2014 Oct 28 2
12 23485397 HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation. 2013 Jun 2
13 23536002 Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46. 2013 Jan 14 1
14 23717325 Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis. 2013 2
15 23814058 Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. 2013 Aug 16 1
16 21932419 Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function. 2012 Aug 15 1
17 21248071 Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis. 2011 Mar 15 1
18 21715331 Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility. 2011 Aug 19 3
19 22110707 Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. 2011 3
20 20018442 Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation. 2010 Jun 1 1
21 20418953 Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival. 2010 Apr 14 2
22 20514025 Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. 2010 Aug 5 1
23 20573984 Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. 2010 Aug 15 6
24 20849851 Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells. 2010 Oct 8 2
25 19015637 PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. 2009 Feb 5 1
26 19714248 Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. 2009 Aug 28 1
27 19828042 HIPK2 modulates p53 activity towards pro-apoptotic transcription. 2009 Oct 14 2
28 18395248 Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells. 2008 Jun 1
29 18536714 Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. 2008 Jul 1
30 18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. 2008 Nov 1 2
31 17203463 Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. 2007 Mar 1 2
32 17332358 Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. 2007 Mar 1 3
33 17960875 Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. 2007 Dec 5
34 16601678 Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. 2006 May 3 1
35 16984892 c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP. 2006 Nov 17 2
36 15708980 Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. 2005 Feb 22 2
37 15897882 HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage. 2005 Aug 18 2
38 14729469 Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. 2004 Feb 15 1
39 15526030 Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. 2004 Nov 24 2
40 12907596 PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. 2003 Aug 1 1
41 11740489 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. 2002 Jan 1
42 11780126 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. 2002 Jan 3