Title : PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

Pub. Date : 2003 Aug 1

PMID : 12907596






1 Functional Relationships(s)
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1 Whereas the architecture of HIPK domains is PML independent, HIPK2-mediated enhancement of p53-dependent transcription, p53 serine 46 phosphorylation and the antiproliferative function of HIPK2 strictly rely on the presence of PML. Serine homeodomain interacting protein kinase 2 Homo sapiens