Fatty Acids, Nonesterified

free fatty acid receptor 1 ; Rattus norvegicus

12 Article(s)
Pub. Year
#Total Relationships
1 31426858 Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells. 2019 Aug 19 2
2 28731171 Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. 2017 Sep 2
3 24666736 CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients. 2014 Mar 25 1
4 23911664 GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats. 2013 Dec 5 1
5 22332921 Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors. 2012 May 1
6 21319751 Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists. 2011 Mar 10 3
7 21752941 TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. 2011 Oct 1
8 20888730 DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. 2010 Nov 1
9 24900210 Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist. 2010 Sep 9 1
10 19217448 Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat. 2009 Mar 1
11 17101212 Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. 2007 Jan 15 5
12 16214394 GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion. 2005 Oct 1