Title : Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors.

Pub. Date : 2012 May

PMID : 22332921






1 Functional Relationships(s)
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1 By testing various FFAs, it was found that FFA-induced suppression of basal and glucose-stimulated insulin secretion was attenuated by an increase in the degree of unsaturation of the FFAs and GPR40 expression in response to FFA treatment in INS-1 cells. Fatty Acids, Nonesterified free fatty acid receptor 1 Rattus norvegicus