Methylnitrosourea

O-6-methylguanine-DNA methyltransferase ; Mus musculus







18 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 31841318 Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. 2020 Feb 17 1
2 24519900 Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice. 2014 Mar 2
3 12663516 DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors. 2003 Mar 5
4 13679151 Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. 2003 Oct 7 5
5 11276365 MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure. 2001 Feb 7
6 10657972 A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. 2000 Feb 4
7 10391687 Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. 1999 Jun 24 2
8 10469609 Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis. 1999 Sep 1
9 9560238 Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. 1998 Apr 28 3
10 9163672 Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting. 1997 May 2
11 9192819 Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. 1997 Jun 15 5
12 9366529 Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase. 1997 Oct 23 5
13 7767963 The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene. 1995 May 3
14 8062258 Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. 1994 Sep 1 2
15 1834328 Analysis of N-methyl-N-nitrosourea-induced mutations in a shuttle vector plasmid propagated in mouse O6-methylguanine-DNA methyltransferase-deficient cells in comparison with proficient cells. 1991 Dec 1 2
16 2052012 Characterization of O6-methylguanine-DNA methyltransferase in transgenic mice introduced with the E. coli ada gene. 1991 May 3
17 2054779 Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene. 1991 Jul 1 1
18 2826035 Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents. 1988 Jan 1