zafirlukast

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







4 Article(s)
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1 22108774 Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations. 2012 May 2
2 20931329 The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast. 2011 Feb 1
3 16167835 Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme. 2005 Sep 4
4 11888331 Pharmacokinetic profile of zafirlukast. 2002 1