PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16167835-0	2005	Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.	zafirlukast	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-45	
22108774-1	2012	PURPOSE: Zafirlukast is a substrate of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4) in vitro, but the role of these enzymes in its metabolism in vivo is unknown.	zafirlukast	9-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-91	
22108774-1	2012	PURPOSE: Zafirlukast is a substrate of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4) in vitro, but the role of these enzymes in its metabolism in vivo is unknown.	zafirlukast	9-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99	
20931329-2	2011	Like montelukast, zafirlukast is a substrate of CYP2C9 and CYP3A4 and a potent inhibitor of CYP2C8 in vitro.	zafirlukast	18-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65	
16167835-9	2005	In addition, zafirlukast proved to be a mechanism-based inhibitor of CYP3A4 activity in human liver microsomes and in microsomes containing cDNA-expressed CYP3A4.	zafirlukast	13-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-75	
16167835-9	2005	In addition, zafirlukast proved to be a mechanism-based inhibitor of CYP3A4 activity in human liver microsomes and in microsomes containing cDNA-expressed CYP3A4.	zafirlukast	13-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161	
16167835-12	2005	In summary, zafirlukast dehydrogenation to an electrophilic alpha,beta-unsaturated iminium intermediate may be associated with idiosyncratic hepatotoxicity and/or cause drug-drug interactions through inactivation of CYP3A4.	zafirlukast	12-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	216-222	
11888331-15	2002	Inhibition of the CYP2C9 and CYP3A isoenzymes by zafirlukast has been reported in vitro.	zafirlukast	49-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-34