| 1 |
33048135 | Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam. | 2021 Nov 9 |
1 |
| 2 |
33674271 | Metabolic Retroversion of Piperaquine (PQ) via Hepatic Cytochrome P450-Mediated N-Oxidation and Reduction: Not an Important Contributor to the Prolonged Elimination of PQ. | 2021 May |
2 |
| 3 |
30902024 | Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. | 2020 Feb |
2 |
| 4 |
31286572 | In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug-drug interactions. | 2020 Feb |
3 |
| 5 |
31929398 | Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine. | 2020 Apr |
1 |
| 6 |
30912932 | Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. | 2019 Apr 16 |
1 |
| 7 |
31028057 | Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach. | 2019 Jul |
1 |
| 8 |
31312984 | Theoretical study on the mechanism of N- and α-carbon oxidation of lapatinib catalyzed by cytochrome P450 monooxygenase. | 2019 Jul 16 |
1 |
| 9 |
31605674 | Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. | 2019 Dec |
2 |
| 10 |
29129847 | Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models. | 2018 Feb 9 |
1 |
| 11 |
30087611 | Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. | 2018 |
1 |
| 12 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
1 |
| 13 |
27692933 | Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases. | 2017 Sep 10 |
1 |
| 14 |
29061956 | Oxycodone Resistance Due to Rifampin Use in an Osteosarcoma Patient with Tuberculosis. | 2017 Oct 24 |
1 |
| 15 |
25737032 | Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking. | 2016 Aug |
1 |
| 16 |
26741368 | Effect of Methamphetamine on Spectral Binding, Ligand Docking and Metabolism of Anti-HIV Drugs with CYP3A4. | 2016 |
2 |
| 17 |
27457784 | Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans. | 2016 Oct |
1 |
| 18 |
25327846 | Introduction of a nitrogen-containing side chain appended on C-10 of cethromycin leads to reduced CYP3A4 inhibition (WO2014049356A1). | 2015 Jan |
1 |
| 19 |
25382218 | Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes. | 2015 Jun |
1 |
| 20 |
25651456 | In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids. | 2015 Apr 20 |
2 |
| 21 |
26104860 | Effects of medetomidine and its active enantiomer dexmedetomidine on N-demethylation of ketamine in canines determined in vitro using enantioselective capillary electrophoresis. | 2015 Nov |
1 |
| 22 |
26276083 | Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps. | 2015 Nov 4 |
1 |
| 23 |
26456786 | Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP). | 2015 Oct |
1 |
| 24 |
24841887 | The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application. | 2014 Jul 15 |
1 |
| 25 |
24860154 | Bedaquiline: a review of human pharmacokinetics and drug-drug interactions. | 2014 Sep |
2 |
| 26 |
25121773 | Effects of aprepitant on the pharmacokinetics of controlled-release oral oxycodone in cancer patients. | 2014 |
1 |
| 27 |
25505590 | Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug. | 2014 Jun |
1 |
| 28 |
23361230 | 2-methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques. | 2013 Apr |
1 |
| 29 |
23404373 | Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate. | 2013 May |
2 |
| 30 |
23550066 | The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. | 2013 Jun |
1 |
| 31 |
23666577 | Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder. | 2013 Jun |
1 |
| 32 |
23774830 | Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn. | 2013 Jul |
1 |
| 33 |
23988488 | Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse. | 2013 Nov 15 |
1 |
| 34 |
22106171 | Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. | 2012 Mar |
2 |
| 35 |
22187487 | Excretion, metabolism, and pharmacokinetics of 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide, a selective cannabinoid receptor antagonist, in healthy male volunteers. | 2012 Mar |
1 |
| 36 |
22949220 | Electrophoretically mediated microanalysis for characterization of the enantioselective CYP3A4 catalyzed N-demethylation of ketamine. | 2012 Nov |
2 |
| 37 |
20849451 | Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice. | 2011 Mar |
1 |
| 38 |
21983822 | Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro. | 2011 Oct |
1 |
| 39 |
22023129 | Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. | 2011 Nov |
1 |
| 40 |
19897389 | Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine. | 2010 Jul |
1 |
| 41 |
20977456 | Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes. | 2010 Nov |
1 |
| 42 |
18836708 | Voriconazole drastically increases exposure to oral oxycodone. | 2009 Mar |
1 |
| 43 |
18256203 | Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans. | 2008 May |
1 |
| 44 |
18292673 | Role of CYP2B6 in stereoselective human methadone metabolism. | 2008 Mar |
1 |
| 45 |
18311908 | Characterization of type II ligands in CYP2C9 and CYP3A4. | 2008 Mar 27 |
1 |
| 46 |
18647303 | Maraviroc: in vitro assessment of drug-drug interaction potential. | 2008 Oct |
1 |
| 47 |
17259447 | Enantiomeric metabolic interactions and stereoselective human methadone metabolism. | 2007 Apr |
2 |
| 48 |
17433262 | Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. | 2007 Jun 15 |
1 |
| 49 |
17460031 | Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics. | 2007 Aug |
3 |
| 50 |
17576805 | Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. | 2007 Sep |
1 |