Acetaminophen

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







23 Article(s)
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1 34031539 Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo. 2021 Sep 1
2 34430783 In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology. 2021 Aug 1
3 31393259 Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. 2020 2
4 32455711 Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties. 2020 May 21 1
5 30587336 Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives. 2019 Jan 29 6
6 31305025 Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease. 2019 Nov 1
7 31892214 Flow-Based Three-Dimensional Co-Culture Model for Long-Term Hepatotoxicity Prediction. 2019 Dec 27 1
8 28341123 Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation. 2017 May 6 3
9 28729056 Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury. 2017 Aug 15 1
10 28951593 MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. 2017 Sep 26 2
11 26869439 Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. 2016 Feb 1
12 24498291 Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s. 2014 1
13 22913318 Targeting the pregnane X receptor in liver injury. 2012 Nov 1
14 21111054 Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. 2011 May-Jun 1
15 21194699 In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment. 2011 Feb 11 1
16 19219744 Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. 2009 Jan 2
17 19460945 Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. 2009 Aug 6
18 15078344 Characterization of the acetaminophen-induced degradation of cytochrome P450-3A4 and the proteolytic pathway. 2004 Apr 5
19 11811955 The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells. 2002 Feb 1 5
20 10678302 Phenytoin as a possible cause of acetaminophen hepatotoxicity: case report and review of the literature. 2000 Feb 1
21 10741631 Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. 2000 Mar 1
22 9246016 The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. 1997 Jul 2
23 8387297 Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. 1993 Apr 22 4