Guanosine Diphosphate

Rac family small GTPase 1 ; Homo sapiens







88 Article(s)
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1 35215978 Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome? 2022 Feb 14 1
2 35583642 Targeting Cancer by Using Nanoparticles to Modulate RHO GTPase Signaling. 2022 1
3 33848152 Mechanistic Differences of Activation of Rac1P29S and Rac1A159V. 2021 Apr 22 1
4 33977469 Regulation of the Small GTPase Ras and Its Relevance to Human Disease. 2021 1
5 34321603 Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway. 2021 Sep 2
6 32178475 Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis. 2020 Mar 12 3
7 32314182 Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance. 2020 Sep 3
8 30621237 RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression. 2019 Jan 4 1
9 30765861 Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells. 2019 Jun 3
10 30891502 Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR. 2019 Mar 5
11 30981505 Structural and functional characterization of fast-cycling RhoF GTPase. 2019 May 28 1
12 31330900 The Intrinsic GDP/GTP Exchange Activities of Cdc42 and Rac1 Are Critical Determinants for Their Specific Effects on Mobilization of the Actin Filament System. 2019 Jul 21 1
13 31457101 Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1. 2019 Aug 6
14 31888228 Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output. 2019 Dec 16 1
15 27588611 The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses. 2018 Jul 4 1
16 29196061 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. 2018 Apr 1
17 29432733 DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation. 2018 Feb 26 2
18 29920300 6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling. 2018 Aug 1
19 29967243 Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor. 2018 Sep 15 3
20 30407917 Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion. 2018 Nov 1 2
21 30544910 Post-Translational Modification and Subcellular Distribution of Rac1: An Update. 2018 Dec 11 2
22 27314616 GEFs: Dual regulation of Rac1 signaling. 2017 Apr 3 4
23 28803992 P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway. 2017 Oct 28 2
24 26911374 Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression. 2016 Apr 1
25 27628050 Rho GTPases: Regulation and roles in cancer cell biology. 2016 Oct 2
26 27835684 Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation. 2016 2
27 25561548 Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling. 2015 Jan 20 1
28 26438819 p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. 2015 Nov 27 3
29 26484896 Comparing the Affinity of GTPase-binding Proteins using Competition Assays. 2015 Oct 8 1
30 25014207 Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. 2014 3
31 25305482 RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication. 2014 Nov 7 1
32 23284172 RAC1P29S is a spontaneously activating cancer-associated GTPase. 2013 Jan 15 1
33 23322732 Balanced Tiam1-rac1 and RhoA drives proliferation and invasion of pancreatic cancer cells. 2013 Mar 2
34 23382236 Transforming mutations of RAC guanosine triphosphatases in human cancers. 2013 Feb 19 1
35 23612479 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. 2013 Aug 1
36 23733346 A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. 2013 Jun 10 2
37 23967341 FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling. 2013 1
38 24146998 Molecular dynamic simulation reveals damaging impact of RAC1 F28L mutation in the switch I region. 2013 2
39 22157745 A palmitoylation switch mechanism regulates Rac1 function and membrane organization. 2012 Feb 1 2
40 22705156 WNT-3a modulates platelet function by regulating small GTPase activity. 2012 Jul 30 1
41 22714419 Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling. 2012 Jan-Mar 1
42 21439300 A model of localised Rac1 activation in endothelial cells due to fluid flow. 2011 Jul 7 1
43 21873980 Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. 2011 Aug 26 1
44 22446552 Cell motility: The necessity of Rac1 GDP/GTP flux. 2011 Nov 1 2
45 19890090 Small G proteins in islet beta-cell function. 2010 Feb 1
46 20395297 The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. 2010 Jun 18 1
47 20709748 Splice variants of SmgGDS control small GTPase prenylation and membrane localization. 2010 Nov 12 1
48 18505730 Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. 2008 Aug 8 4
49 18518859 Activation of NADPH oxidase 1 in tumour colon epithelial cells. 2008 Oct 1 4
50 17122362 Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration. 2007 Feb 1