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heat shock protein 90 alpha family class A member 1 ; Homo sapiens







150 Article(s)
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101 15004035 Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. 2004 May 21 2
102 15062560 Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90. 2004 Jan 15 2
103 15077173 Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. 2004 Jul 8 2
104 15152036 Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. 2004 May 19 2
105 15212536 New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. 2004 Jun 30 1
106 15239664 Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90. 2004 Jul 15 1
107 15265741 A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors. 2004 Aug 15 1
108 15271357 Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin. 2004 Jul 1
109 15358769 Hsp90 chaperones wild-type p53 tumor suppressor protein. 2004 Nov 19 1
110 15360086 Radicicol potentiates heat-induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity. 2004 Jul 5
111 15364548 Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells. 2004 Sep 15 1
112 15501584 Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways. 2004 Nov 30 1
113 15744362 N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules. 2004 Dec 2
114 12471035 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. 2003 Feb 14 1
115 12678776 Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. 2003 May 2
116 12729599 Filter binding assay for the geldanamycin-heat shock protein 90 interaction. 2003 Jun 1 1
117 12820659 Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. 2003 Spring 2
118 12842893 Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. 2003 Sep 12 2
119 12964162 NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol. 2003 Sep 5 1
120 14529382 Overview: translating Hsp90 biology into Hsp90 drugs. 2003 Oct 1
121 14529384 Natural product origins of Hsp90 inhibitors. 2003 Oct 1
122 14529387 Development of radicicol analogues. 2003 Oct 5
123 14529388 Development of purine-scaffold small molecule inhibitors of Hsp90. 2003 Oct 1
124 11772336 HSP90 as a new therapeutic target for cancer therapy: the story unfolds. 2002 Jan 3
125 11779851 Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. 2002 Mar 22 1
126 11911945 Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. 2002 Feb 25 2
127 11923316 hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90. 2002 Jun 7 1
128 11960322 Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. 2002 Apr 2
129 12391259 Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. 2002 Nov 2
130 12530016 ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells. 2002 Sep-Oct 2
131 11306353 A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. 2001 Mar 1
132 11347901 Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins. 2001 Mar 2
133 11360191 UCS15A, a non-kinase inhibitor of Src signal transduction. 2001 Apr 19 1
134 11447118 The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. 2001 Jul 16 1
135 11448926 Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. 2001 Jul 1
136 11473354 Hsp90: chaperoning signal transduction. 2001 Sep 1
137 11686693 Concise asymmetric syntheses of radicicol and monocillin I. 2001 Nov 7 1
138 11707594 Host cell factor requirement for hepatitis C virus enzyme maturation. 2001 Nov 20 1
139 11749701 A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. 2001 Dec 2
140 11800023 Stereospecific antitumor activity of radicicol oxime derivatives. 2001 Dec 5
141 10793137 Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck). 2000 May 1
142 10816560 Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity. 2000 Jul 28 2
143 10945979 The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. 2000 Nov 24 2
144 10979978 Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. 2000 Sep 15 4
145 15687592 Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression. 2000 1
146 9925731 Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. 1999 Jan 28 5
147 10383157 KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. 1999 Jun 15 3
148 10478836 Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. 1999 Sep 5
149 9632140 Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. 1998 May 1
150 9672245 Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. 1998 Jun 5