Vorinostat

heat shock protein 90 alpha family class A member 1 ; Homo sapiens







17 Article(s)
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1 30365122 Vorinostat enhances gefitinib‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation. 2019 Jan 3
2 28915577 Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha. 2017 Aug 22 4
3 27382012 Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells. 2016 Sep 2
4 25119188 Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells. 2015 Jan 8
5 24903226 A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer. 2014 Jul 5
6 22200869 Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo. 2012 Apr 2
7 22825030 Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells. 2012 Sep 1
8 21637290 SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. 2011 Dec 1
9 20028416 Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma. 2010 Apr 1
10 20039095 The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. 2010 Mar 1
11 19440035 Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells. 2009 Jul 2
12 18342836 Histone deacetylase inhibitor SAHA induces ERalpha degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling. 2008 May 1 3
13 17397803 FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70. 2007 May 18 2
14 17699868 Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. 2007 Aug 15 1
15 15625278 Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change. 2005 Apr 1
16 16144943 Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2. 2005 Sep 1 3
17 14679005 Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. 2003 Dec 1 3