Pub. Date : 2015 Jan
PMID : 25119188
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | We found that HSP90 was cleaved to 55 kDa protein after treatment with histone deacetylase (HDAC) inhibitors including suberoylanilide hydroxamic acid (SAHA) in several leukemia cell lines. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | We found that HSP90 was cleaved to 55 kDa protein after treatment with histone deacetylase (HDAC) inhibitors including suberoylanilide hydroxamic acid (SAHA) in several leukemia cell lines. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | The SAHA-induced cleavage of HSP90 was blocked by a pan-caspase inhibitor, z-VAD-fmk, implying that the process is dependent on caspase activity. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | SAHA induced generation of reactive oxygen species (ROS), and the cleavage of HSP90 was blocked by a ROS scavenger N-acetylcystein (NAC). | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | Treatment of the cells with caspase 10 inhihitor, but not other inhibitors of caspases activated by SAHA, prevented cleavage of HSP90 by SAHA. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 7 | SAHA-induced ROS generation and HSP90 cleavage were dependent on newly synthesized unknown proteins. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 8 | Taken together, our results suggest that the cleavage of HSP90 by SAHA is mediated by ROS generation and caspase 10 activation. | Vorinostat | heat shock protein 90 alpha family class A member 1 | Homo sapiens |