Fatty Acids

free fatty acid receptor 1 ; Mus musculus







35 Article(s)
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1 33103454 GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice. 2021 Jan 1 1
2 34349026 CPL207280, a Novel G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1-Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals. 2021 Oct 2
3 34489696 FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice. 2021 3
4 34774873 GPR40 agonist inhibits NLRP3 inflammasome activation via modulation of nuclear factor-κB and sarco/endoplasmic reticulum Ca2+-ATPase. 2021 Dec 15 1
5 31740001 Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1. 2020 Jan 29 2
6 31812788 A high-fat diet enriched in medium chain triglycerides triggers hepatic thermogenesis and improves metabolic health in lean and obese mice. 2020 Mar 2
7 32728158 Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease. 2020 Jul 29 1
8 31002464 Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion. 2019 Nov 1
9 31664108 GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells. 2019 Oct 29 1
10 29748290 Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion. 2018 Oct 4
11 29931581 The involvement of free fatty acid-GPR40/FFAR1 signaling in chronic social defeat stress-induced pain prolongation in C57BL/6J male mice. 2018 Aug 2
12 27611773 GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone. 2017 Feb 4
13 28723961 Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. 2017 1
14 29031729 Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance. 2017 Oct 4
15 29568424 Optical control of GPR40 signalling in pancreatic β-cells. 2017 Nov 1 1
16 26974308 Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. 2016 Apr 1
17 27700527 The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1. 2016 Nov 2
18 26408932 Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure. 2015 Dec 3
19 23331570 Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition. 2013 Jun 2
20 23335512 The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. 2013 Mar 1 2
21 23831422 Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. 2013 Oct 10 2
22 24154510 GPR40 and GPR120 fatty acid sensors are critical for postoral but not oral mediation of fat preferences in the mouse. 2013 Dec 15 1
23 22768248 Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. 2012 1
24 22820510 G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. 2012 Oct 2
25 19369060 Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice. 2010 Apr 1
26 20573884 Taste preference for fatty acids is mediated by GPR40 and GPR120. 2010 Jun 23 3
27 19720802 Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. 2009 Nov 2
28 18559658 The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. 2008 Sep 2
29 18617622 Modulation of osteoclastogenesis by fatty acids. 2008 Nov 2
30 18678612 Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. 2008 Nov 4
31 17395749 GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. 2007 Apr 3
32 17500511 Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. 2007 Jun 14 1
33 16267104 Mouse GPR40 heterologously expressed in Xenopus oocytes is activated by short-, medium-, and long-chain fatty acids. 2006 Mar 2
34 16702987 Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. 2006 Jul 2
35 16044321 Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. 2005 Nov 4