Tretinoin

cytochrome P450 family 26 subfamily A member 1 ; Homo sapiens







145 Article(s)
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51 23601821 2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation. 2013 Jun 1 1
52 23688132 Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics. 2013 6
53 23946489 Cytochrome p450 cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells. 2013 Oct 4 3
54 24043786 Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. 2013 Oct 1 1
55 22020119 Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases. 2012 Jan 1 5
56 22415012 A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis. 2012 May 9 2
57 22542753 Co-cultures of enterocytes and hepatocytes for retinoid transport and metabolism. 2012 Dec 1
58 22727372 Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold. 2012 Jul 15 2
59 22989911 Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. 2012 Oct 15 1
60 23053054 Retinoic acid synthesis and metabolism are concurrent in the mouse uterus during peri-implantation. 2012 Dec 2
61 23071109 Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes. 2012 Dec 7 2
62 20606468 CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells. 2011 8
63 21428449 Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. 2011 Apr 28 1
64 21521770 Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. 2011 Aug 3
65 21529158 Cytochrome P450s in the regulation of cellular retinoic acid metabolism. 2011 Aug 21 2
66 21838328 Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). 2011 Oct 13 3
67 21906690 Functional properties and substrate characterization of human CYP26A1, CYP26B1, and CYP26C1 expressed by recombinant baculovirus in insect cells. 2011 Nov-Dec 7
68 22179182 Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin. 2011 Dec 3
69 19935721 Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1. 2010 Feb 25 4
70 20200558 Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line. 2010 Apr 1
71 20409737 Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency. 2010 Jul 2
72 20513361 The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid. 2010 Sep 15 7
73 20682464 Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver. 2010 Sep 15 5
74 18992717 Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase. 2009 Jan 15 8
75 19100254 Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways. 2009 Feb 15 1
76 19120344 The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes. 2009 Mar 2
77 19147277 The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. 2009 May 8 1
78 19171200 The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes. 2009 Mar 5
79 19294396 Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. 2009 Aug 8
80 19519282 The role of CYP26 enzymes in retinoic acid clearance. 2009 Aug 10
81 19525031 Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne. 2009 Aug 2
82 19853565 Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 2009 Oct 1
83 17998248 Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. 2008 Feb 15 1
84 18059332 A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett's associated adenocarcinoma. 2008 May 8 6
85 18093970 Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. 2008 Feb 29 1
86 18241852 CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid. 2008 Mar 15 13
87 18502188 Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell. 2008 Jul 2
88 18927157 Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. 2008 Nov 1
89 26621242 Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). 2008 Jun 3
90 17164423 Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. 2007 Jan 7
91 17218384 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. 2007 May 15 3
92 17244623 Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. 2007 Mar 16 1
93 17276435 Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure. 2007 Jun 1
94 17460545 The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. 2007 Mar 4
95 17510468 CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells. 2007 Jul 4
96 17663992 Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 2007 Sep 14 1
97 17714122 Oral R115866 in the treatment of moderate to severe plaque-type psoriasis. 2007 Sep 1
98 16463413 Mutational screening of the CYP26A1 gene in patients with caudal regression syndrome. 2006 Feb 3
99 16778795 Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models. 2006 Nov 1
100 16837774 Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells. 2006 1