Pregnenolone Carbonitrile

cytochrome P450, family 3, subfamily a, polypeptide 62 ; Rattus norvegicus







19 Article(s)
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1 29548889 Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. 2018 May 1 1
2 21402137 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. 2011 May 30 2
3 19389273 Effects of pregnenolone-16alpha-carbonitrile on vitamin E status and protein levels of antioxidant enzymes in male rats fed a vitamin E-supplemented diet. 2009 1
4 18427905 The use of a high-throughput luminescent method to assess CYP3A enzyme induction in cultured rat hepatocytes. 2008 May-Jun 1
5 17652830 Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat. 2007 May-Jun 1
6 16673044 Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain. 2006 Jul 2
7 16751264 P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile. 2006 Sep 1
8 16125621 Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo. 2005 Sep-Oct 1
9 11854146 Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. 2002 Mar 2
10 12011477 Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. 2002 Jun 2
11 10467955 The effect of pregnenolone 16alpha-carbonitrile on the pharmacokinetics and metabolism of dapsone in rats. 1999 Jul 1
12 10553723 High throughput ribonuclease protection assay for the determination of CYP3A mRNA induction in cultured rat hepatocytes. 1999 Aug 1
13 10570047 Regulation of rat hepatic hydroxysteroid sulfotransferase (SULT2-40/41) gene expression by glucocorticoids: evidence for a dual mechanism of transcriptional control. 1999 Dec 1
14 9468221 Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene. 1998 Jan 1
15 9881931 Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver. 1998 Nov 2 1
16 8845857 Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. 1996 Feb 1
17 7628309 Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. 1995 Mar 1
18 8001226 Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. 1994 Dec 1
19 20692951 Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures. 1994 Aug 1