Title : Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures.

Pub. Date : 1994 Aug

PMID : 20692951






1 Functional Relationships(s)
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1 In vivo pretreatment with pregnenolone-16alpha-carbonitrile (cytochrome P-450 (CYP) 3A induction) enhanced the toxicities of enalapril, fosinopril and quinapril but did not affect the response to captopril. Pregnenolone Carbonitrile cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus