Phenobarbital

cytochrome P450, family 3, subfamily a, polypeptide 62 ; Rattus norvegicus







34 Article(s)
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1 31270302 The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats. 2019 1
2 27624558 The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1. 2016 Sep 14 1
3 22245121 Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR. 2012 Mar 11 1
4 18022748 Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. 2008 Jan 14 1
5 16581946 Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants. 2006 Jul 1
6 16815962 Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4alpha expression. 2006 Oct 1
7 15288127 CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. 2004 Sep 1 1
8 15345328 GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A. 2004 Oct 1 1
9 12515593 Metabolism of territrem a in liver microsomes from male wistar rats: 3. Cytochrome p-450 isoforms catalyzing tra metabolism. 2002 Dec 27 1
10 11698173 Cytochrome P450 activity in control and induced long-term cultures of rat hepatocyte spheroids. 2001 Dec 1
11 11201056 Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases. 2000 4
12 10064562 Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes. 1999 Mar 1
13 10215695 Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes. 1999 May 2
14 9448743 Induction of hepatic cytochrome P450 2B and P450 3A isozymes in rats by zolazepam, a constituent of Telazol. 1998 Jan 15 1
15 9537282 Comparative pharmacodynamics of CYP2B induction by DDT, DDE, and DDD in male rat liver and cultured rat hepatocytes. 1998 Mar 27 1
16 9578594 Posttranslational elevation of cytochrome P450 3A levels and activity by dimethyl sulfoxide. 1998 May 1 1
17 9705199 Evidence for involvement of cAMP-dependent pathway in the phenobarbital-induced expression of a novel hamster cytochrome P450, CYP3A31. 1998 Aug 15 1
18 8990268 Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. 1997 Jan 1 1
19 7587963 Induction of liver microsomal cytochrome P450 in cynomolgus monkeys. 1995 Jul 1
20 7628308 N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes. 1995 Mar 1
21 7873612 A novel CYP3 gene from female rats. 1995 Feb 21 1
22 8001226 Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. 1994 Dec 1
23 8003039 Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein. 1994 Jun 15 1
24 8053924 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. 1994 Jul 19 1
25 8081427 Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment. 1994 Jun 1
26 8209390 Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes. 1994 Jun 1
27 8104124 Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. 1993 Jul-Aug 1
28 8129853 Possible existence of a CYP3A protein in liver microsomes from female rats. 1993 Dec 1
29 8442654 Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture. 1993 Feb 15 1
30 8477751 Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes. 1993 Apr 15 2
31 1306117 Induction of various cytochromes CYP2B, CYP2C and CYP3A by phenobarbitone in non-human primates. 1992 Aug 1
32 1417000 Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. 1992 Nov 1 1
33 1417986 Induction of a pleiotropic response by phenobarbital and related compounds. Response in various inbred strains of rats, response in various species and the induction of aldehyde dehydrogenase in Copenhagen rats. 1992 Oct 20 2
34 1930280 The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro. 1991 Sep 27 1