Title : Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.

Pub. Date : 2000

PMID : 11201056






4 Functional Relationships(s)
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1 Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
2 Different inhibitors or activators of protein kinases or phosphatases were assessed for their ability to modulate PB-induction of CYP2B and CYP3A mRNA expression. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
3 The present data further suggested that Ca2+/calmodulin-dependent protein kinases II (independently of Ca2+) and extracellular signal-regulated kinases 1/2 (ERK1/2) might function respectively as positive and negative regulator in the PB-induction of CYP2B and CYP3A. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
4 We conclude that a complex network of phosphorylation/dephosphorylation events might be crucial for PB-induction of rat CYP2B and CYP3A. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus